Actively Recruiting

Phase Not Applicable
Age: 18Years - 64Years
All Genders
Healthy Volunteers
NCT06144203

The Influence of Aerobic Exercise on Consolidation of Fear Extinction Learning in PTSD

Led by University of Alabama, Tuscaloosa · Updated on 2024-02-15

120

Participants Needed

1

Research Sites

265 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This study aims to test whether aerobic exercise performed after fear extinction learning improves cognitive, physiological, and neural indices of extinction recall in a sample of trauma-exposed men and women with and without posttraumatic stress disorder (PTSD). Participants will complete a clinical intake visit (Day 0), followed by a three-day fear conditioning (day 1), fear extinction + activity (day 2), and fear extinction recall (day 3) protocol.

CONDITIONS

Official Title

The Influence of Aerobic Exercise on Consolidation of Fear Extinction Learning in PTSD

Who Can Participate

Age: 18Years - 64Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Male or female sex
  • Right-handed
  • Age 18-64 years
  • Current diagnosis of PTSD with an index event involving interpersonal violence exposure (e.g., physical/sexual assault), or
  • Interpersonal violence exposure without PTSD (e.g., physical/sexual assault)
Not Eligible

You will not qualify if you...

  • Current substance use disorder (except alcohol, nicotine, or cannabis)
  • Acute suicidality
  • History of bipolar or psychotic disorder
  • Psychiatric medication changes or additions within past 4 weeks (6 weeks for fluoxetine)
  • Use of medications affecting neurovascular properties relevant to BOLD fMRI
  • History of neurological disorders or diseases such as traumatic brain injury, epilepsy, or seizures
  • Loss of consciousness over 10 minutes
  • Intellectual disabilities (IQ below 70)
  • Developmental disorders
  • MRI contraindications (e.g., internal ferromagnetic objects, surgical implants, shrapnel)
  • Claustrophobia or inability to lie still in confined space
  • Physical disabilities preventing task performance (e.g., blindness or deafness)
  • Positive pregnancy test
  • Cochlear implant
  • Implanted neurostimulator
  • Vulnerable populations including pregnant women, those lacking consent capacity, prisoners, those unable to read consent materials, or individuals related to study researchers
  • History of chest pain during physical activity
  • Bone, joint, cardiac, or other medical conditions that may worsen with physical activity
  • Asthma
  • Unsafe to engage in aerobic exercise per Physical Activity Readiness Questionnaire without doctor's approval
  • Recent Percutaneous Coronary Intervention or acute myocardial infarction within 6 weeks
  • Unstable arrhythmias or implanted cardiac defibrillator shocks in past 3 months
  • Any condition that might put participant at risk per principal investigator
  • Conditions, medications, or implants that may degrade MRI image quality (e.g., nonremovable dental implants)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Wade Hall - University of Alabama

Tuscaloosa, Alabama, United States, 35487

Actively Recruiting

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Research Team

K

Kevin Crombie, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

3

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