Actively Recruiting
Comparison of Wound Healing Complications After Anterior Total Hip Arthroplasty Using Povidone-iodine or Chlorhexidine as Antiseptic Wash
Led by F. Johannes Plate · Updated on 2026-02-05
420
Participants Needed
2
Research Sites
17 weeks
Total Duration
On this page
Sponsors
F
F. Johannes Plate
Lead Sponsor
I
Irrimax Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the effect of two different antiseptic washing solutions on wound healing after total hip replacement surgery. The study aims to find out if washing the surgical wound with povidone-iodine or chlorhexidine solution affects the healing process and the risk of wound healing complications. This research is important because the best washing solution for cleaning the wound and promoting healing is currently unknown. Participants will be randomly assigned to one of two groups. One group will have their surgical wound washed with a 3-minute chlorhexidine lavage followed by saline, while the other group will receive a 3-minute povidone-iodine lavage followed by saline. All participants will undergo standard total hip replacement surgery without other changes. The study will provide the washing solutions used during surgery. After surgery, participants will attend standard follow-up visits at 2 weeks and 6 weeks. During these visits, photographs of the surgical incision will be taken and stored in the medical record to assess wound healing and scar appearance using a standardized method. The research team will track wound healing complications, hospital readmissions, and any additional surgeries from medical records up to 90 days after surgery to evaluate outcomes.
CONDITIONS
Brief Title
Influence of Antiseptic Washes on Wound Healing Complications After THA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of osteoarthritis or avascular necrosis of the femoral head
- Failed conservative management
- Indicated for total hip replacement surgery
- Adults aged 18 years or older
You will not qualify if you...
- Known allergy to chlorhexidine
- Known allergy to povidone-iodine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day
Participants receive either a chlorhexidine or povidone-iodine lavage of the surgical wound following total hip replacement surgery.
1 visit (in-person)
Duration - Up to 90 days after surgery
Participants attend standard postoperative visits where healing of the surgical incision is evaluated and postoperative complications are monitored.
Visits at 2 weeks and 6 weeks post-op with incision photos taken; additional visits as part of standard care
Trial Site Locations
Total: 2 locations
1
UPMC East
Monroeville, Pennsylvania, United States, 15146
Actively Recruiting
2
UPMC Shadyside
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
Research Team
F
Frank J Plate, MD, PhD
D
Dana Farrell, BS,PMP
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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