Actively Recruiting
Influence of Healing Time on the Outcomes of Alveolar Ridge Preservation in Periodontally Compromised Extraction Sockets
Led by Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Updated on 2025-02-19
42
Participants Needed
1
Research Sites
251 weeks
Total Duration
On this page
Sponsors
S
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Lead Sponsor
G
Geistlich Pharma AG
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to histologically, clinically, and radiographically evaluate the healing sequelae of periodontally compromised extraction sockets grafted with Bio-Oss Collagen® at 3 and 6 months following tooth extraction in molar sites. The main question it aims to answer is: Does healing time influence the histologic, clinical, and radiographic outcomes following socket grafting (alveolar ridge preservation) in periodontally compromised extraction sockets. Researchers will compare a healing time of 3 months to a healing time of 6 months (conventional healing duration) to see if a shorter duration is viable for implant placement. Participants will: Take a cone-beam computed tomography (CBCT) scan to prepare for the surgical procedure. Undergo tooth extraction and the extraction socket will be grafted with Bio-Oss Collagen® and a collagen membrane Bio-Gide® will be placed to stabilize the graft material. Return at 2 weeks for suture removal and either 3- or 6-months post-extraction for implant placement. Return at 2 weeks post-implant placement for suture removal, 3 months for prosthesis fabrication, 4 months for final prosthesis loading, and 1 year post-loading.
CONDITIONS
Official Title
Influence of Healing Time on the Outcomes of Alveolar Ridge Preservation in Periodontally Compromised Extraction Sockets
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- ASA (American Society of Anesthesia) status I or II
- Need for molar extraction due to periodontal disease with or without chronic endodontic involvement, meeting criteria for periodontitis stage III/IV
- Radiographic evidence of bone dehiscence on at least one socket wall with horizontal defect height >50% of root length on CBCT scans
- Radiographic evidence of at least 3 mm of residual bone wall height
- Presence of at least one adjacent tooth to the extraction site
- Treatment plan includes tooth replacement with an implant-supported fixed dental prosthesis
You will not qualify if you...
- Extraction of multiple adjacent teeth
- Acute infection associated with the tooth to be extracted or adjacent teeth
- Current smokers of more than 10 cigarettes per day
- Uncontrolled diabetes mellitus (HbA1c >7.0)
- Any active oral or systemic acute infections
- Currently receiving chemotherapy or radiotherapy, or history of radiotherapy in the head and neck area
- Diseases or medications that may impair normal wound healing
AI-Screening
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Trial Site Locations
Total: 1 location
1
Shanghai Ninth People's Hospital
Shanghai, China, 201999
Actively Recruiting
Research Team
X
Xinbo Yu, BDS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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