Actively Recruiting
Influence of Human Albumin Supplementation on Kidney Dysfunction After Liver Transplantation
Led by Rennes University Hospital · Updated on 2025-12-09
400
Participants Needed
8
Research Sites
161 weeks
Total Duration
On this page
Sponsors
R
Rennes University Hospital
Lead Sponsor
M
Ministry of Health, France
Collaborating Sponsor
AI-Summary
What this Trial Is About
To verify whether albumin administration to achieve serum concentration above 30g/L (treated group) and its maintenance within plasmatic physiologic range (above 30 g/L) for five days diminishes rate of AKI at Day 7 after liver transplantation as compared to restrained albumin administration (when serum concentration is at 20 g/L or below (control)).
CONDITIONS
Official Title
Influence of Human Albumin Supplementation on Kidney Dysfunction After Liver Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female subjects equal or above 18 yrs old.
- Recipients of primary liver allografts from a deceased donor (including after cardiac death) and as a single organ (liver only).
- Capability of understanding the purpose and risks of the study.
- Written informed consent
You will not qualify if you...
- Fulminant hepatitis
- Kidney injury at baseline (Estimated Glomerular Filtration Rate < 50 ml/min in Modification of diet in renal disease-6) including hepatorenal syndrome
- Use of an induction agent Basiliximab at liver transplantation
- Protected person (adults legally protected, under judicial protection, guardianship, or supervision), person deprived of their liberty
- At the time of randomisation, participation to another interventional study
AI-Screening
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Trial Site Locations
Total: 8 locations
1
08_CHRU de Tours Hôpital Trousseau
Chambray-lès-Tours, France, 37170
Actively Recruiting
2
03_APHP Hôpital Beaujon
Clichy, France, 92110
Actively Recruiting
3
04_CHU de Lille Hôpital Huriez
Lille, France, 59000
Not Yet Recruiting
4
05_HCL Hôpital de la Croix Rousse
Lyon, France, 69004
Actively Recruiting
5
06_CHU de Montpellier Hôpital St Eloi
Montpellier, France, 34295
Actively Recruiting
6
02_CHU de Bordeaux - Hôpital Haut Leveque
Pessac, France, 33604
Actively Recruiting
7
01_CHU de Rennes Hôpital Pontchaillou
Rennes, France, 35000
Actively Recruiting
8
09_APHP Hôpital Paul Brousse
Villejuif, France, 94804
Not Yet Recruiting
Research Team
L
Loïc JACOB
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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