Actively Recruiting
Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
Led by Yale University · Updated on 2025-08-03
63
Participants Needed
2
Research Sites
99 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to find out about the effects of a drug called mavoglurant on alcohol consumption.
CONDITIONS
Official Title
Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 21 to 50 years
- Ability to read English at a 6th grade level or higher
- Meet DSM-V criteria for moderate or severe Alcohol Use Disorder
- Average weekly alcohol consumption of 30-70 standard drinks for men and 20-65 drinks for women
You will not qualify if you...
- Seeking alcohol treatment or have been in alcohol treatment within the past 6 months
- Meet DSM-V criteria for substance use disorder except tobacco or mild cannabis use disorder
- Positive urine drug screens for opiates, cocaine, benzodiazepines, or barbiturates on more than one baseline appointment
- Psychotic or severe psychiatric disorders
- Regular use of psychoactive drugs except stable antidepressant dose for at least 2 months
- Medical conditions contraindicating alcohol or mavoglurant use
- Clinically significant lab abnormalities (AST, ALT, bilirubin, creatinine above limits)
- Neurological trauma, delirium, hallucinations, or unstable medical conditions
- Alcohol withdrawal scores of 8 or greater or history of repeated significant withdrawals
- Women who are pregnant or nursing
- Refusal to use reliable birth control
- Dislike of spirits (hard liquor) provided during the study
- Use of investigational drugs within 4 weeks prior to first dose
- Heavy drinking days in 2 days prior to intake with negative ethyl glucuronide test
- Blood donation within 6 weeks prior to study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Connecticut Mental Health Center (SAC and SATU)
New Haven, Connecticut, United States, 06511
Actively Recruiting
2
Yale New Haven Hospital
New Haven, Connecticut, United States, 06512
Actively Recruiting
Research Team
S
Suchitra Krishnan, PhD
CONTACT
T
Thomas Liss
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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