Actively Recruiting
Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis
Led by University of Alabama at Birmingham · Updated on 2025-12-19
28
Participants Needed
1
Research Sites
244 weeks
Total Duration
On this page
Sponsors
U
University of Alabama at Birmingham
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to determine the daily rate of endogenous synthesis of oxalate using fasted urine collection and a low-oxalate controlled diet in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
CONDITIONS
Official Title
Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- History of MASLD with liver fat content greater than 5%
- Normal kidney function
- Stable medication for diabetes mellitus for at least 1 month if applicable
- Willingness to follow fixed diets, stop dietary supplements, and attend study visits at UAB
You will not qualify if you...
- Age under 18 years
- Inaccurate 24-hour urine collections
- Liver fat content less than 5%
- Liver cirrhosis
- Other chronic liver diseases or viral hepatitis
- History of alcoholism within 2 years prior to enrollment
- Contraindication to Magnetic Resonance Imaging
- Chronic kidney disease with estimated glomerular filtration rate below 60 ml/min/1.73m2
- Type 1 diabetes mellitus or insulin treatment
- Uncontrolled diabetes
- Pregnancy, lactation, or intention to become pregnant
- Uncontrolled hypertension
- Use of weight loss medication, SGLT2 inhibitors, GLP-1 receptor agonists, osteoporosis medication, or chronic NSAIDs
- History of gastric or intestinal surgery altering oxalate absorption
- Chronic fat malabsorption
- Use of immunosuppressive medications
- Known immunocompromised status
- Active malignancy or treatment within last 12 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
Research Team
K
Kyle D Wood, MD
CONTACT
S
Sonia Fargue, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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