Actively Recruiting
The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function
Led by Auburn University · Updated on 2024-05-29
60
Participants Needed
1
Research Sites
256 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Black individuals are at increased cardiovascular disease risk. The central goal of the study is to determine if mitochondrial reactive oxygen species influence blood vessel function and nervous system regulation of blood pressure differentially in black, compared to white individuals. These findings may help to explain a potential mechanism that contributes to racial disparities in blood pressure and cardiovascular disease risk. A secondary goal is to determine if mitochondrial reactive oxygen species improves blood pressure and vascular function in individuals with elevated blood pressure and stage 1 hypertension.
CONDITIONS
Official Title
The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Are between the ages of 19-75.
- Have blood pressure no higher than 150/90 mmHg.
- Have a BMI below 35 Kg/m2 and are otherwise healthy.
- Do not have metabolic diseases such as diabetes or renal disease.
- Do not have pulmonary disorders like COPD or cystic fibrosis.
- Do not have cardiovascular diseases including peripheral vascular, cardiac, or cerebrovascular conditions.
- Have no medical issues preventing exercise or blood donation, such as cardiovascular problems or painful arthritis.
- Are not currently smoking, using smokeless tobacco, nor have smoked within the past 12 months.
You will not qualify if you...
- Known allergy to MitoQ.
- High blood pressure above 150/90 mmHg.
- Low blood pressure below 90/50 mmHg.
- History of cardiovascular disease.
- History of cancer.
- History of diabetes.
- History of kidney disease.
- Obesity with BMI greater than 30 kg/m2.
- Smoking or tobacco use.
- Current pregnancy.
- Nursing mothers.
- Communication barriers.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Kinesiology Building
Auburn, Alabama, United States, 36849
Actively Recruiting
Research Team
A
Austin T Robinson, PhD
CONTACT
Z
Zachary J Hutchison, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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