Actively Recruiting
Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery
Led by Insel Gruppe AG, University Hospital Bern · Updated on 2024-12-13
110
Participants Needed
1
Research Sites
395 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients undergoing non-cardiac vascular surgery.
CONDITIONS
Official Title
Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent
- Scheduled for elective or non-emergent non-cardiac vascular surgery under general anesthesia with intubation
- Have proven coronary artery disease and undergoing high- or intermediate-risk surgery according to European guidelines
- Or have two or more risk factors for coronary artery disease and undergoing high- or intermediate-risk surgery according to European guidelines
You will not qualify if you...
- Acute coronary event within 30 days before surgery
- Acute congestive heart failure
- Hemodynamic instability before anesthesia induction requiring vasopressor or inotrope infusion
- Atrial fibrillation or other severe arrhythmia
- Severe pulmonary disease needing oxygen therapy or stage 4 COPD, severe carbon monoxide diffusion impairment, or severe pulmonary hypertension
- Preoperative oxygen saturation below 90% on room air
- Increased risk of oxygen toxicity (e.g., recent chemotherapy, bleomycin treatment, airway laser surgery)
- Scheduled thoracic cavity surgery
- ICU admission for respirator weaning and delayed extubation
- Pre-existing surgical site infection
- Active systemic inflammatory response syndrome or sepsis
- Pregnancy
- Emergency surgery planned within less than 12 hours
- Ambulatory surgery
- Baseline high-sensitive Troponin T level above 65 ng/L
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Bern University Hospital, Inselspital
Bern, Switzerland, 3010
Actively Recruiting
Research Team
D
Dominik P Guensch, MD
CONTACT
J
Jan-Oliver Friess, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
4
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