Actively Recruiting

Phase Not Applicable
Age: 18Years - 89Years
All Genders
ID03307018

Assessment of Influence of Routine Postoperative Systematic Bronchial Aspiration With Flexible Bronchoscope on Occurrence of Pulmonary Complications After Anatomical Lung Resections: a Prospective Randomized Controlled Study.

Led by Wielkopolskie Centrum Pulmonologii i Torakochirurgii · Updated on 2024-08-09

200

Participants Needed

1

Research Sites

4 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying the effects of routine postoperative bronchoscopy on lung complications after anatomical lung resections. Respiratory complications like atelectasis and pneumonia often occur due to retained bronchial secretions that are not fully cleared by usual suctioning through an intubation tube. This trial evaluates whether using a thin flexible bronchoscope for systematic aspiration of secretions immediately after surgery can better clear the bronchial tree and reduce such complications. Participants will be randomly assigned to one of two groups: one receiving systematic bronchial aspiration using a flexible bronchoscope after surgery, and a control group receiving standard care without bronchoscopy. Surgery involves pulmonary lobectomy under general anesthesia with standard lung ventilation techniques. For the bronchoscopy group, the procedure will be done systematically to remove secretions from all main, lobar, and segmental bronchi. All patients will receive standard postoperative pain management and monitoring. During the study, participants will be closely monitored with physical exams, chest X-rays on the day of surgery and postoperative days 1 and 2, and blood tests including C-reactive protein levels. The study team will assess lung complications like atelectasis, pneumonia, and related scores within three days after surgery. Other outcomes include atrial fibrillation occurrence, surgery duration, ICU admission, and hospital stay. Safety and complications such as bleeding or infection will also be recorded. The total study duration for participants includes the immediate postoperative period up to three days after surgery.

CONDITIONS

Brief Title

Influence of Postoperative Bronchoscopy on Pulmonary Complications After Anatomical Lung Resections.

Who Can Participate

Age: 18Years - 89Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Pulmonary lobectomy.
  • Patients must be informed and must sign and give written informed consent.
Not Eligible

You will not qualify if you...

  • Wedge resection, segmentectomy, pneumonectomy.

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery

Duration - Day of surgery

Participants undergo anatomical lung resection surgery under general anesthesia. At the end of surgery, suctioning of secretions from large airways is performed.

1 visit (in-person, surgery day)

Postoperative Treatment

Duration - Up to 3 days after surgery

Participants are randomly assigned to receive either routine postoperative care or additional systematic bronchial aspiration using flexible bronchoscopy immediately after surgery.

Daily assessments for up to 3 days

Postoperative Follow-up

Duration - Up to 3 days after surgery

Participants are monitored for pulmonary complications including atelectasis, pneumonia, atrial fibrillation, and inflammation markers through physical exams, chest x-rays, and blood tests.

Chest x-rays on surgery day evening, postoperative days 1 and 2; daily physical exams twice a day; CRP blood test before surgery and 72 hours after surgery

Trial Site Locations

Total: 1 location

1

Wielkopolskie Centrum Pulmonologii i Torakochirurgii

Poznan, Wielkopolska, Poland, 62-007

Actively Recruiting

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Research Team

Ł

Łukasz Gąsiorowski, MD

C

Cezary Piwkowski, Prof

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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Published Research Related To This Trial

Summary of the British Thoracic Society guidelines for advanced diagnostic and therapeutic flexible bronchoscopy in adults.

I A Du Rand, P V Barber, J Goldring...

https://pubmed.ncbi.nlm.nih.gov/22003155