Actively Recruiting
Influence of Short-Term Antibiotic Therapy on Exercise
Led by Rutgers, The State University of New Jersey · Updated on 2025-07-24
40
Participants Needed
2
Research Sites
117 weeks
Total Duration
On this page
Sponsors
R
Rutgers, The State University of New Jersey
Lead Sponsor
C
Colorado State University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The gut microbiome refers to the trillions of bacteria that inhabit the stomach and other regions involved in the digestion of food, including the intestines. Compelling studies of animals (rodents) suggest that the health of the gut microbiome may influence skeletal muscle function and exercise performance. To date, there have been no similar observations reported in humans. A common experimental approach in animal studies to temporarily disrupt the gut microbiome is through the use of antibiotic therapies. Azithromycin is an antibiotic medicine prescribed to humans for the treatment of mild to moderate infections caused by bacteria. The purpose of the proposed project is to determine the influence of short-term (5-days) antibiotic therapy (azithromycin) on exercise performance in young, healthy adults. Treadmill exercise performance will be compared in two groups of adults before and after 5-days ingestion of azithromycin, or a placebo (something that has no physical effect).
CONDITIONS
Official Title
Influence of Short-Term Antibiotic Therapy on Exercise
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 40 years
- Identify as male or female
- Able and willing to run on a treadmill for 60 minutes without stopping
- Completed at least 150 minutes per week of moderate-to-vigorous physical activity during the past year
- Participants assigned female at birth must currently use hormonal contraception
You will not qualify if you...
- Use of antibiotics or probiotics within the past 12 weeks
- Currently pregnant, trying to become pregnant, or breastfeeding
- Any contraindication to exercise
- Previous diagnosis of heart disease, peripheral vascular disease, high blood pressure, stroke, heart murmur, sickle cell anemia, or pulmonary disorder
- Previous allergic reaction to azithromycin, erythromycin, or related macrolide or ketolide drugs
- History of cholestatic jaundice or liver dysfunction linked to prior azithromycin use
- Diagnosis of pneumonia within the past 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Human Performance Clinical Research Lab
Fort Collins, Colorado, United States, 80521
Actively Recruiting
2
Nutrition, and Exercise Metabolism Lab
New Brunswick, New Jersey, United States, 08901
Actively Recruiting
Research Team
S
Sara C Campbell, PhD
CONTACT
D
Daniel D DeSio, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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