Study of How Regular Sleep Patterns Affect Cardiovascular, Metabolic, and Pain Health in Adults Ages 18 to 50

What this Trial Is About

Researchers are investigating how consistent sleep patterns affect cardiovascular and metabolic health in healthy adults aged 18 to 40 years. The study aims to understand if improving the regularity of sleep timing can positively influence heart, blood vessel, and metabolic functions. A subgroup with chronic pain will also be studied to assess the impact of sleep regularity on pain outcomes. Participants in the lowest third for sleep regularity will follow a 12-week intervention maintaining a consistent sleep onset time within 30 minutes of their chosen bedtime. The control group will continue their usual sleep patterns. Data collection includes two weeks of sleep monitoring using actigraphy and sleep logs, in-laboratory visits for circadian and vascular assessments, blood draws for biomarker analysis, and ambulatory monitoring with blood pressure cuffs and continuous glucose monitors. Participants will attend baseline and 12-week laboratory visits for blood samples and health measurements. Throughout the study, they will complete daily surveys and wear devices to track sleep and cardiovascular data. Researchers will measure changes in melatonin levels, sleep regularity, heart rate, blood pressure, metabolic markers, body composition, and pain severity. The study duration is approximately 12 weeks, with multiple assessments to evaluate the effects of sleep regularity on health.

The Influence of Sleep on Cardiovascular Outcomes