Study of How Timing of Dental Implant Placement Affects Early Healing and Molecular Changes

What this Trial Is About

Researchers are investigating the early healing processes after dental implant placement, focusing on the timing of implant insertion either immediately after tooth extraction or after a delay. This two-centre pilot study aims to understand how different timings affect the expression of inflammatory, blood vessel growth, and bone-related biomarkers in saliva and peri-implant crevicular fluid PICF during the first month following implant placement. The study also explores wound healing and osseointegration, which is the integration of the implant with the bone. Participants will be randomly assigned to one of two groups immediate implant placement on the same day as tooth extraction, or delayed implant placement after complete bone healing 4 to 6 months later. Both groups will receive a tapered bone level implant with guided bone regeneration using bone graft material. Implants will be loaded with a dental prosthesis three months after placement. The study involves detailed procedures such as measurements and use of surgical templates to guide implant positioning. During the study, participants will attend 10 to 11 visits over at least 16 months for assessments including saliva and PICF sampling at multiple timepoints up to 30 days after implant placement. Researchers will monitor blood flow, soft tissue volume, bone levels, oral hygiene, gum health, pocket depths, esthetic scores, implant survival, and patient satisfaction up to six months after implant loading. These evaluations will help understand the molecular and clinical healing outcomes depending on the timing of implant placement.

Influence of Timing of Implant Placement on Early Healing Molecular Events