Actively Recruiting
Influence of Timing of Implant Placement on Early Healing Molecular Events
Led by Queen Mary University of London · Updated on 2025-11-19
24
Participants Needed
1
Research Sites
118 weeks
Total Duration
On this page
Sponsors
Q
Queen Mary University of London
Lead Sponsor
U
University of Belgrade
Collaborating Sponsor
AI-Summary
What this Trial Is About
Dental implants have been on the market for several years and they are routinely used to replace single/multiple missing teeth with a high success rate. However, there is still a limited number of studies comparing the influence of timing of implant placement on wound healing. In addition, there is no data available on the signaling pathways and the expression of healing biomarkers involved in the early stages of osseointegration after immediate implant placement (IP) or delayed implant placement (DP). The primary objective of this study is to describe changes in the expression of inflammatory, angiogenesis and osseous biomarkers of saliva at 1, 3, 7, 15 and 30 days and of PICF at 3, 7, 15 and 30 days after immediate implant placement (IP) compared with delayed placement (DP).
CONDITIONS
Official Title
Influence of Timing of Implant Placement on Early Healing Molecular Events
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 25 years or older
- Good or controlled medical and psychological health
- Good oral hygiene with full mouth plaque score 20% or less
- Presence of a tooth in the aesthetic region (incisor to second premolar) needing extraction and single implant rehabilitation
- For immediate placement group: intact extraction socket with facial bone wall at least 1 mm thick, no acute infection, and sufficient bone for implant stability
- At least one neighboring natural tooth
- Functional occlusion with minimum of four occlusal units (pairs of occluding posterior teeth)
- Willingness to read, understand, and sign informed consent
You will not qualify if you...
- Known systemic diseases severely affecting bone metabolism (e.g., Cushing's syndrome, Crohn's disease, rheumatoid arthritis, osteoporosis, type I diabetes, uncontrolled type II diabetes)
- Self-reported HIV or viral hepatitis
- Self-reported alcoholism or chronic drug abuse
- Current smokers or those who quit less than 3 months ago, including vape/e-cigarette users
- Pregnancy or lactation
- Chronic treatment with medications affecting oral status or bone metabolism within 1 month before baseline (e.g., bisphosphonates, hormone therapy, immunosuppressants)
- Chronic treatment with anticoagulants, corticosteroids, immunosuppressants, or drugs affecting blood coagulation
- Antibiotic or anti-inflammatory therapy in the month before baseline
- Untreated caries or uncontrolled periodontal disease
- Inadequate keratinized tissue width less than 2 mm in the treatment area
- Physical handicaps affecting oral hygiene ability in implant area
- Need for maxillary sinus lift surgery before implant placement
- Self-reported bruxism
- Unwillingness to receive animal-derived biomaterials for guided bone regeneration
- Known psychological disorders or limited mental capacity/language skills preventing informed consent or study compliance
- Other severe medical or psychiatric conditions or lab abnormalities increasing risk or interfering with study results as judged by investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
Centre for Oral Clinical Research
London, United Kingdom, E1 2AD
Actively Recruiting
Research Team
M
Miljana Bacevic
CONTACT
J
Jeniffer Perussolo
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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