Actively Recruiting
Influence of Timing of Implant Placement on Early Healing Molecular Events: A Two-centre, Parallel Group, Pilot Study
Led by Queen Mary University of London · Updated on 2025-11-19
24
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
Q
Queen Mary University of London
Lead Sponsor
U
University of Belgrade
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the early healing processes after dental implant placement, focusing on the timing of implant insertion either immediately after tooth extraction or after a delay. This two-centre pilot study aims to understand how different timings affect the expression of inflammatory, blood vessel growth, and bone-related biomarkers in saliva and peri-implant crevicular fluid (PICF) during the first month following implant placement. The study also explores wound healing and osseointegration, which is the integration of the implant with the bone. Participants will be randomly assigned to one of two groups: immediate implant placement on the same day as tooth extraction, or delayed implant placement after complete bone healing (4 to 6 months later). Both groups will receive a tapered bone level implant with guided bone regeneration using bone graft material. Implants will be loaded with a dental prosthesis three months after placement. The study involves detailed procedures such as measurements and use of surgical templates to guide implant positioning. During the study, participants will attend 10 to 11 visits over at least 16 months for assessments including saliva and PICF sampling at multiple timepoints up to 30 days after implant placement. Researchers will monitor blood flow, soft tissue volume, bone levels, oral hygiene, gum health, pocket depths, esthetic scores, implant survival, and patient satisfaction up to six months after implant loading. These evaluations will help understand the molecular and clinical healing outcomes depending on the timing of implant placement.
CONDITIONS
Brief Title
Influence of Timing of Implant Placement on Early Healing Molecular Events
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 25 years or older
- Good or controlled medical and psychological health
- Good oral hygiene with full mouth plaque score of 20% or less
- Presence of a tooth in the aesthetic region (incisor to second premolar) needing extraction and single implant replacement
- Extraction socket must have intact walls, facial bone wall at least 1 mm thick, no acute infection, and sufficient bone for implant stability (for immediate placement group)
- At least one neighboring natural tooth
- Functional bite with at least four pairs of occluding posterior teeth
- Willingness to sign informed consent after full study explanation
You will not qualify if you...
- Known systemic diseases severely affecting bone metabolism (e.g., Cushing's syndrome, Crohn's disease, rheumatoid arthritis, osteoporosis, diabetes type I or uncontrolled type II)
- Self-reported HIV or viral hepatitis
- Self-reported alcoholism or chronic drug abuse
- Current smokers or those who quit less than 3 months ago, including vape/e-cigarette users
- Pregnancy or lactation
- Recent (within 1 month) chronic use of medications affecting bone or oral status (e.g., bisphosphonates, hormone therapy, immunosuppressants)
- Chronic use of anticoagulants, corticosteroids, or other blood-affecting drugs
- Recent antibiotic or anti-inflammatory therapy (within 1 month)
- Untreated caries or uncontrolled periodontal disease
- Inadequate keratinized tissue width less than 2 mm at implant site
- Physical handicaps interfering with oral hygiene
- Need for maxillary sinus lift surgery before implant placement
- Self-reported bruxism
- Unwillingness to receive animal-derived bone graft materials
- Known psychological disorders or limited mental capacity affecting consent or participation
- Other severe medical or psychiatric conditions increasing risk or impairing study results interpretation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Same day or 4 to 6 months after tooth extraction
Participants receive a dental implant either immediately after tooth extraction or after complete bone healing (4 to 6 months later). Guided bone regeneration is performed as needed.
1 visit (in-person)
Duration - 30 days after implant placement
Participants are monitored for early healing molecular events including inflammatory and osseous biomarker changes, blood flow, and soft tissue volume changes over the first month after implant placement.
Visits on days 1, 3, 7, 15, and 30 after implant placement
Duration - At 3 months after implant placement
Participants receive conventional implant loading approximately 3 months after implant placement.
1 visit (in-person)
Duration - 6 months after implant loading
Participants are followed for clinical outcomes including soft tissue volume changes, bone level, plaque and bleeding scores, probing depth, esthetic scores, implant survival, and patient satisfaction.
Visits at implant loading and 6 months after implant loading
Trial Site Locations
Total: 1 location
1
Centre for Oral Clinical Research
London, United Kingdom, E1 2AD
Actively Recruiting
Research Team
M
Miljana Bacevic
J
Jeniffer Perussolo
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here