Actively Recruiting

Phase 4
Age: 20Years - 50Years
All Genders
Healthy Volunteers
NCT06031298

Influence of Various Healing Intervals on Alveolar Ridge Preservation Using Demineralized Dentin Graft: A Randomized Clinical Trial

Led by Ain Shams University · Updated on 2025-01-31

30

Participants Needed

1

Research Sites

113 weeks

Total Duration

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AI-Summary

What this Trial Is About

Statement of the problem: The alveolar ridge undergoes various remodeling processes following tooth extraction, but the ridge resorption continues over time, resulting in hard and soft tissue loss which complicates prosthodontic rehabilitation whether by dental implants or tooth supported prosthesis. Aim of the study: The aim of the study is to assess the influence of the different time intervals on the healing of the demineralized dentin graft in alveolar ridge preservation (ARP) procedures. Materials and methods: 30 patients with hopeless teeth requiring extraction in maxillary non molar areas and requiring replacement with dental implants, will be enrolled and recruited from the outpatient clinic, faculty of dentistry, ain shams university according to the inclusion criteria. They will be randomly allocated into three equal groups. Group A (n=10) alveolar ridge preservation will be done with demineralized dentin graft and re-entry at 12 weeks, group B (n=10) alveolar ridge preservation will be done with demineralized dentin graft and re-entry at 18 weeks and group C (n=10) alveolar ridge preservation will be done with demineralized dentin graft and re-entry at 24 weeks. Radiographic assessment will be done using CBCT to the arch of interest and another cone beam will be done prior to the implant placement at 11, 17 and 23 weeks based on the study group and a volumetric assessment will be done with digital subtraction. At the respective times core biopsy will be taken for the histological assessment, and the implant placement will be done with the implant primary stability recorded using Ostell. Postoperative medication will be prescribed to the patient and postoperative instructions will be explained in detail. Follow-up will be performed. Data collected will be tabulated and statistically analyzed.

CONDITIONS

Official Title

Influence of Various Healing Intervals on Alveolar Ridge Preservation Using Demineralized Dentin Graft: A Randomized Clinical Trial

Who Can Participate

Age: 20Years - 50Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Systemically healthy patients (ASA I)
  • Age between 20 and 50 years
  • Non-molar maxillary teeth needing extraction
  • Extraction sites with intact bone walls or no more than one wall with less than 50% bone height loss
Not Eligible

You will not qualify if you...

  • Teeth or nearby teeth with acute infections
  • Smokers
  • Patients with uncontrolled diabetes (HbA1c >7.0), liver or kidney failure, active infections, chemotherapy/radiotherapy history affecting head and neck
  • Pregnant or breastfeeding women
  • Patients unwilling or unable to comply with dental visits or sign consent

AI-Screening

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Trial Site Locations

Total: 1 location

1

Faculty of Dentistry - Ain Shams University

Cairo, Egypt

Actively Recruiting

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Research Team

M

Mohamed A Mohamed

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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