Potential Influence of Pre-fabricated and Customized Anatomical Zirconia Abutments in the Peri-implant Region for Single-tooth Implant-supported Prosthetic Restorations

What this Trial Is About

Researchers are evaluating the effects of two types of abutments—pre-fabricated standardized titanium and customized anatomical zirconia—on the health of tissues around single implant-supported posterior teeth. This randomized controlled clinical trial focuses on how these abutments impact implant biocompatibility, peri-implant tissue stability, bone loss seen on X-rays, and the quality of life related to oral health. The study builds upon a previous phase where participants had tooth extractions, alveolar preservation, and implant placement with a six-month healing period. Participants who have successfully integrated implants will be randomly assigned to receive prosthetic rehabilitation with either titanium abutments or zirconia abutments, both supporting single zirconia crowns in back teeth. The prosthetic and lab procedures follow standardized digital protocols. The study includes follow-up visits at prosthesis delivery and 1, 3, 6, and 12 months afterward to monitor changes and responses. During the study, researchers will collect samples of peri-implant crevicular fluid and biofilm for biomolecular analysis and measure periodontal health, mucosa thickness, and bone levels using standardized X-rays. Digital scans will assess soft tissue volume and stability. The main outcome is microbial colonization at the implant sites over 12 months. Secondary outcomes include demographic data, clinical parameters, bone level changes, and soft tissue stability. This research aims to improve understanding of how abutment materials influence long-term implant health.

Influence of Zirconia Abutments on Peri-Implant Tissues in Single-Tooth Restorations