Actively Recruiting
Influenza Vaccination Strategy for Patients With Hematologic Malignancy
Led by Asan Medical Center · Updated on 2026-03-24
60
Participants Needed
1
Research Sites
125 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized controlled trial evaluates and compares the immunogenicity of three different influenza vaccine formulations: high-dose trivalent (HD-IIV3), MF59-adjuvanted quadrivalent (aIIV4), and standard-dose trivalent (SD-IIV3) vaccines. The study population consists of patients with hematologic malignancies, including those undergoing autologous stem cell transplantation or CAR-T cell therapy. The primary goal is to identify which vaccine strategy elicits the most robust antibody and T cell-mediated immune responses in this severely immunocompromised population
CONDITIONS
Official Title
Influenza Vaccination Strategy for Patients With Hematologic Malignancy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 19 years or older
- Confirmed diagnosis of hematologic malignancy including non-Hodgkin lymphoma, Hodgkin lymphoma, acute leukemia, chronic leukemia, or plasma cell disorders
You will not qualify if you...
- Difficulty with repeated venipuncture or blood sampling such as poor vascular access or bleeding tendency
- Cognitive or psychiatric impairment preventing understanding or cooperation with study procedures
- Known hypersensitivity to influenza vaccine components
- Influenza vaccination within the preceding 6 months
- Any condition deemed clinically inappropriate for study participation by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Asan Medical Center
Seoul, South Korea
Actively Recruiting
Research Team
S
So Yun Lim, MD, PhD
CONTACT
S
Sung-Han Kim, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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