Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06511401

Informing Pain Treatment Using Pharmacogenomic Analysis

Led by University of Chicago · Updated on 2026-05-04

800

Participants Needed

1

Research Sites

191 weeks

Total Duration

On this page

Sponsors

U

University of Chicago

Lead Sponsor

N

National Human Genome Research Institute (NHGRI)

Collaborating Sponsor

AI-Summary

What this Trial Is About

This is a randomized, prospective study to evaluate the effects of preemptive pharmacogenomic (PGx) testing on opioid dosing decisions/selections and pain score in cancer patients.

CONDITIONS

Official Title

Informing Pain Treatment Using Pharmacogenomic Analysis

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Persons receiving ongoing oncology care at the University of Chicago Medical Center for whom near-future opioid pain medication therapy is anticipated
  • At least 18 years of age
Not Eligible

You will not qualify if you...

  • Taking an opioid at the time of enrollment or within the past 30 days
  • Currently undergoing palliative radiation
  • Have undergone or are being considered for bone marrow, liver, or kidney transplantation
  • History of or active blood cancer such as leukemia
  • Chronic kidney disease with Glomerular filtration rate below 30/mL/min/1.73m2
  • Liver dysfunction defined by total bilirubin ≥1.5 mg/dL or AST and ALT ≥2.5 times upper limit of normal (≥5 times if hepatic metastases present)
  • Unable to understand and give informed consent
  • Known to be pregnant at enrollment
  • Previously or currently enrolled in another pharmacogenomic genotyping study or previously undergone pharmacogenomic genotyping for the gene(s) of interest

AI-Screening

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Trial Site Locations

Total: 1 location

1

University of Chicago Medicine Comprehensive Cancer Center

Chicago, Illinois, United States, 60637

Actively Recruiting

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Research Team

C

Clinical Trials Intake

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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