Treatment Study of Lidocaine and Steroids Infused into the Middle Meningeal Artery to Manage Headaches After Spontaneous Subarachnoid Hemorrhage

What this Trial Is About

Researchers are evaluating whether infusing lidocaine, with or without steroids, into the middle meningeal artery MMA can help relieve severe headaches in patients who have experienced a spontaneous subarachnoid hemorrhage SAH. This Phase 2 trial focuses on patients with aneurysmal SAH classified as Hunt and Hess Grades 1-2. The study also aims to assess the safety of this treatment approach and its potential to reduce opioid use for pain management. The study involves three groups of 15 patients each one group receiving 50 mg of lidocaine alone, another receiving 50 mg of lidocaine combined with 10 mg of dexamethasone a steroid, and a control group receiving no injection. Medication is given during a standard brain angiogram procedure. Participants will be closely monitored for changes in pain levels and opioid use over time. Participants will undergo multiple pain assessments using the Visual Analog Scale VAS at baseline and every 4 hours for 24 hours after the procedure. Morphine equivalent usage will be tracked to evaluate opioid needs. Follow-up visits will occur at 1, 3, and 6 months to monitor ongoing pain relief, medication use, and any side effects or complications. The study duration extends through these follow-ups to gather comprehensive outcome data.

Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage