Actively Recruiting
Beyond Inhalational Agents: Dexmedetomidine for Maintenance of General Anesthesia - A Prospective Randomized Clinical Trial
Led by Bakirkoy Dr. Sadi Konuk Research and Training Hospital · Updated on 2026-01-23
150
Participants Needed
1
Research Sites
5 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The trial investigates the use of dexmedetomidine as an alternative to inhalational anesthetic agents for maintaining general anesthesia in patients aged 39 to 99 undergoing elective urological surgeries. It aims to address environmental concerns related to inhalational agents by evaluating dexmedetomidine's potential benefits in the geriatric population. This prospective, randomized clinical study is conducted at a university hospital and includes patients scheduled for procedures such as uretero-renoscopic lithotripsy, transurethral resection of the bladder, percutaneous nephrolithotomy, and transurethral resection of the prostate. Participants are randomly assigned to receive one of two anesthesia maintenance regimens during surgery: dexmedetomidine combined with remifentanil or desflurane combined with remifentanil. All patients receive a standard induction with fentanyl, propofol, and rocuronium before maintenance anesthesia is administered according to group allocation. Anesthesia depth and hemodynamic parameters are continuously monitored throughout the intraoperative period. During and after surgery, researchers collect data on anesthesia depth, hemodynamic stability, pain levels using the Visual Analog Scale, sedation using the Richmond Agitation-Sedation Scale, and recovery quality with the Modified Aldrete Score. Patients are followed postoperatively in the Post-Anesthesia Care Unit and transferred to hospital wards as appropriate. The study measures outcomes during and after surgery to evaluate anesthesia effectiveness and recovery quality, with overall participation lasting through the surgical and immediate postoperative periods.
CONDITIONS
Brief Title
Inhalational Agents Versus Dexmedetomidine for Maintenance of General Anesthesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 39 years or older
- Classified as ASA physical status II-IV
- Scheduled for elective endoscopic urological surgery such as URS, TUR-B, PCNL, or TUR-P
- Scheduled for postoperative follow-up in the Post-Anesthesia Care Unit (PACU)
- Able to provide written informed consent
You will not qualify if you...
- Requirement for conversion to open surgery during the perioperative period
- Decline to participate in the study
- Presence of neuropsychiatric disorders like dementia, Parkinson's disease, epilepsy, or history of head trauma
- History of alcohol or substance abuse
- Use of psychoactive medications
- Inability to communicate adequately for any reason
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of the surgical procedure
Participants undergo general anesthesia maintenance with either dexmedetomidine combined with remifentanil or desflurane combined with remifentanil during elective urological surgery.
1 visit (in-person, during surgery)
Duration - Until postoperative day 1
Participants are monitored in the Post-Anesthesia Care Unit (PACU) and assessed for sedation level and quality of recovery.
1 to 2 visits (in-person)
Trial Site Locations
Total: 1 location
1
Bakirkoy dr. Sadi Konuk
Istanbul, Istanbul, Turkey (Türkiye), 34140
Actively Recruiting
Research Team
N
NALAN SAYGİ EMİR
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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