Actively Recruiting
Inhalational or Intravenous Anesthesia During Surgery for Patients With Colon Cancer, VIVA Study
Led by University of Kansas Medical Center · Updated on 2023-08-30
80
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
U
University of Kansas Medical Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This trial evaluates how inhalational anesthesia (drawn in through the lungs) and total intravenous anesthesia (TIVA) (through a needle in a vein in the arm) change the body's ability to recover from surgery or whether they impact the immune system immediately after surgery in patients with colon cancer. It is unknown whether these types of anesthesia change recovery from surgery or change the chances cancer comes back following surgery. This study may help researchers learn how different types of anesthesia affect recovery from colon cancer surgery.
CONDITIONS
Official Title
Inhalational or Intravenous Anesthesia During Surgery for Patients With Colon Cancer, VIVA Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability of participant or legally authorized representative to understand the study and provide written consent
- Male or female aged 18 years or older on day of consent
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
- Undergoing surgery to remove biopsy-proven colon adenocarcinoma
- Medically fit for colon resection surgery
- Able to complete required study questionnaires
- Willingness to comply with all study procedures and available for the duration of the study
You will not qualify if you...
- Diagnosis of rectal adenocarcinoma
- Currently enrolled in any therapeutic clinical trial (except possible future adjuvant therapy trials approved by investigators)
- Diagnosis of psychiatric illness or social situation limiting study compliance
- Active grade 3 or higher viral, bacterial, or fungal infection within 2 weeks prior to first dose of study treatment
- Prisoner status
- Allergy to eggs, egg products, soybeans, or soy products (contraindication to propofol)
- Personal or first-degree relative history of malignant hyperthermia (contraindication to inhaled anesthetics)
- Diagnosis of inflammatory bowel disease
- Planned multi-visceral surgery such as pelvic exenteration or combined liver and colon resection
- Surgery for unresectable polyps or incomplete polypectomies without biopsy-proven adenocarcinoma
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Kansas Cancer Center
Kansas City, Kansas, United States, 66160
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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