Study of Inhaled Isopropyl Alcohol Compared to Ondansetron and Placebo to Treat Nausea and Vomiting in Children Ages 7 to 17 in a Pediatric Emergency Department

What this Trial Is About

This research aims to find out how well inhaled isopropyl alcohol works to treat nausea and vomiting in children aged 7 to 17 years at a pediatric emergency department. It compares this treatment to the usual oral ondansetron medication and to a placebo using inhaled normal saline. This study is a randomized controlled trial designed to assess which treatment may help reduce nausea symptoms in this young patient group. Participants are randomly assigned to one of three groups inhaled isopropyl alcohol, oral ondansetron tablets, or inhaled normal saline placebo. In the inhaled groups, the pad soaked with the assigned substance is held under the childs nose to inhale deeply during their stay in the emergency department. Those receiving the placebo or isopropyl alcohol may receive ondansetron if symptoms do not improve within 30 minutes. The treatment is given once, with monitoring throughout the emergency visit. During the study, researchers will collect data on nausea severity before treatment and at 10 minutes, 30 minutes, and at discharge using the Baxter Animated Retching Faces nausea score. They will also record vomiting episodes, any side effects, satisfaction from both caregivers and nurses, and length of stay in the emergency department. Data is securely stored and analyzed to understand treatment effects. The total participation time spans the emergency visit, which can be up to 10 hours.

Inhaled Isopropyl Alcohol for Treatment of Nausea