Actively Recruiting
Inhaled Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Post-Infectious Cough: A Single-Center Randomized Controlled Clinical Trial
Led by Shanghai Changzheng Hospital · Updated on 2025-08-05
40
Participants Needed
1
Research Sites
76 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is an exploratory clinical trial. It is intended to investigate the efficacy of mesenchymal stem cell-derived exosome nebulization in the treatment of postinfectious cough through a randomized controlled clinical study, with a view to providing better treatment options for patients with postinfectious cough, improving their quality of life, and providing reference data for the subsequent multi-center clinical trials.
CONDITIONS
Official Title
Inhaled Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Post-Infectious Cough: A Single-Center Randomized Controlled Clinical Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18-60 years
- Diagnosis of post-infectious cough with symptoms lasting 3 to 8 weeks after acute respiratory infection has resolved
- Chest X-rays are normal
- Cough is dry or with small amounts of mucoid phlegm
- Baseline cough visual analog scale score of 60 mm or higher
You will not qualify if you...
- Presence of other causes of cough such as upper airway cough syndrome, eosinophilic bronchitis, gastroesophageal reflux cough, bronchial asthma, COPD, or bronchiectasis
- Serious lung diseases like lung cancer, tuberculosis, or pulmonary fibrosis
- Serious comorbid conditions including cardiovascular, cerebrovascular, liver, kidney, or hematopoietic system diseases
- Current or former smokers who quit less than 6 months ago
- Body temperature of 37.3°C or higher
- Elevated white blood cell or neutrophil count above normal limits
- Abnormal chest X-rays
- History or suspicion of alcohol or drug abuse or mental illness
- Pregnancy, lactation, or planning pregnancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Shanghai changzheng hospital
Shanghai, Shanghai Municipality, China, 200000
Actively Recruiting
Research Team
H
Hao Tang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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