Actively Recruiting
Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Children at Risk Undergoing Sevoflurane Anesthesia
Led by Sun Yat-sen University · Updated on 2026-04-14
204
Participants Needed
2
Research Sites
98 weeks
Total Duration
On this page
Sponsors
S
Sun Yat-sen University
Lead Sponsor
S
Shenzhen Eye Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This randomized controlled study is to evaluate the effectiveness of inhaling penehyclidine hydrochloride in reducing perioperative respiratory adverse events in children at risk undergoing minor elective surgery.
CONDITIONS
Official Title
Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Children at Risk Undergoing Sevoflurane Anesthesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pediatric patients aged 3 to 7 years
- Scheduled to undergo ophthalmic surgery
- At risk of perioperative respiratory adverse events with at least one parent-reported risk factor such as recent cold, wheezing during exercise, frequent wheezing, nocturnal dry cough, eczema, family history of asthma or allergies, or exposure to passive smoke
You will not qualify if you...
- ASA physical classification of IV or higher
- Known cardiopulmonary diseases like uncorrected heart defects, pulmonary hypertension, tumors, or lung structural diseases
- Severe kidney or liver dysfunction (Child-Pugh grade C)
- Neurological or neuromuscular disorders
- Contraindications to penehyclidine hydrochloride
- Inhalation of beta-2 receptor activators, M-receptor blockers, or glucocorticoids within 1 month before surgery
- Allergy to anticholinergic drugs
- Use of endotracheal tube for ventilation
- Known difficult airway
- Severe upper respiratory infections with surgery delay recommended
- Participation in another clinical trial within the last month or six half-lives of the prior study drug
- Parents refusing participation
- Obesity with body mass index over the 95th percentile per WHO guidelines
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, China, 510060
Actively Recruiting
2
Shenzhen Eye Hospital
Shenzhen, Guangdong, China, 518040
Actively Recruiting
Research Team
X
Xiaoliang Gan, PhD
CONTACT
Y
Yanling Zhu, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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