Actively Recruiting
Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior
Led by University of Minnesota · Updated on 2025-06-12
80
Participants Needed
1
Research Sites
188 weeks
Total Duration
On this page
Sponsors
U
University of Minnesota
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to understand why some people act more impulsively when feeling negative emotions, which is called negative urgency. The researchers hope to understand how negative urgency relates to the way networks of brain cells communicate with one another. The researchers will measure negative urgency and brain signals in adolescents aged 13-21 years with depression and suicidal thoughts and behaviors. The main questions it aims to answer are: * Whether a type of brain signaling called cortical inhibition is related to negative urgency * Whether depressed adolescents with suicidal behavior have more problems with cortical inhibition than depressed adolescents with suicidal thoughts only * Whether the relationship between negative urgency and cortical inhibition changes over time Adolescents who participate in the study will complete the following activities at the time they join the study, as well as 6 months and 12 months later: * Interviews with researchers and questionnaires to learn about their thoughts, emotions, and symptoms * A questionnaire about impulsive behaviors and negative urgency * Computerized games that measure brain functions * An MRI scan of the brain * Transcranial magnetic stimulation with electroencephalography (TMS-EEG), a way to measure how brain cells communicate (cortical inhibition) using a magnet placed outside of the head and recording brain signals
CONDITIONS
Official Title
Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 13-21 years inclusive
- Any sex, gender, race, or ethnicity
- Ability to provide written informed consent (18 years or older) or written assent with legal guardian consent (under 18 years)
- Ability to read and communicate verbally and in writing in English
- Current diagnosis of a unipolar depressive episode confirmed by structured diagnostic interview (MINI or MINI-Kid)
- For Dep/SI group: lifetime history of suicidal ideation but no prior suicidal behavior
- For Dep/SB group: lifetime history of suicidal behavior (interrupted, aborted, or actual suicide attempt)
- Access to reliable internet if completing assessments remotely
You will not qualify if you...
- Imminent suicide risk as determined by study psychiatrist
- Current substance use disorder (except caffeine and nicotine) within last month
- Lifetime history of psychosis, hypomania, or mania
- History of autism spectrum disorder or intellectual disability
- Use of antiepileptic medications or chronic benzodiazepines (as-needed benzodiazepines allowed if withheld on test day)
- Pregnancy or suspected pregnancy in those able to become pregnant
- Medical or neurological history increasing risk for TMS or MRI, including seizures, anoxia, serious head injuries, intracranial surgery, or increased intracranial pressure
- Suicide attempt by hanging or strangulation causing anoxia
- Personal or family history of epilepsy
- Presence of metallic implants, pacemakers, or implanted medical devices
- Contraindications to TMS or MRI per safety screening
- Non-removable hair, head, or neck modifications that interfere with TMS or EEG recording
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55414
Actively Recruiting
Research Team
C
Charles P Lewis, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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