Actively Recruiting
Initial Double Sequential External Defibrillation in Out of Hospital Cardiac Arrest
Led by St. Olavs Hospital · Updated on 2025-06-05
356
Participants Needed
1
Research Sites
178 weeks
Total Duration
On this page
Sponsors
S
St. Olavs Hospital
Lead Sponsor
N
Norwegian Air Ambulance Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Double Sequential External Defibrillation (DSED) represents an alternative treatment of refractory ventricular fibrillation (rVF) in out-of-hospital cardiac arrest (OHCA). The procedure consists of two defibrillators that administer shocks at the same time. Currently, the procedure is not initiated before at least three failed attempts with one defibrillator. This can delay the potential benefits of establishing DSED earlier in the treatment. Studies have shown that early defibrillation is crucial for survival in OHCA patients, and in 2022, a clinical trial showed that survival in patients treated with DSED was higher compared to standard treatment. The effect of initiating OHCA treatment is unknown. The DUALDEFIB trial seeks to investigate if treating OHCA patients with DSED as an initial treatment will increase survival and provide improved neurological outcome.
CONDITIONS
Official Title
Initial Double Sequential External Defibrillation in Out of Hospital Cardiac Arrest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with out of hospital cardiac arrest presenting with a shockable rhythm
You will not qualify if you...
- Age below 18 years
- Obvious or suspected pregnancy
- Incarcerated patients
- Preexisting do-not-resuscitate order
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St Olavs Hospital
Trondheim, Norway, 7030
Actively Recruiting
Research Team
J
Jostein R Brede, MD
CONTACT
V
Vegard Nordviste, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here