Actively Recruiting
Initial Oral Antibiotics for Bone and Joint Infections in Children
Led by Rigshospitalet, Denmark · Updated on 2025-04-09
100
Participants Needed
1
Research Sites
128 weeks
Total Duration
On this page
Sponsors
R
Rigshospitalet, Denmark
Lead Sponsor
I
Innovation Fund Denmark
Collaborating Sponsor
AI-Summary
What this Trial Is About
Initial oral antibiotic treatment for children and adolescents with uncomplicated bone and joint infections (BJI) has been found non-inferior to initial IV antibiotics in one randomized controlled trial (RCT). The real-world effectiveness of initial oral antibiotics for children and adolescents with BJI is unclear. This nationwide, prospective, multicenter, real-world cohort study aims to compare the effectiveness and safety of initial oral antibiotic treatment for children and adolescents with uncomplicated BJI in a real-world setting with those who received initial oral antibiotics in our RCT.
CONDITIONS
Official Title
Initial Oral Antibiotics for Bone and Joint Infections in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children and adolescents aged 3 months to 17 years with uncomplicated bone and joint infections
- Treated with initial oral antibiotics
- No risk factors for complicated disease such as severe illness, sepsis, rapid symptom progression, pronounced symptoms, severe pain, pronounced soft tissue involvement, foreign material or post-surgical infection
- No infection with resistant or rare pathogens like Salmonella or MRSA
- No severe comorbidities including immunodeficiency
- Patients who received intravenous antibiotic therapy for less than 24 hours before oral antibiotics
You will not qualify if you...
- Severe illness or sepsis
- Rapid symptom progression
- Pronounced symptoms including severe pain
- Pronounced soft tissue involvement
- Presence of foreign material or post-surgical infection
- Infection with resistant or rare pathogens, for example, Salmonella or MRSA
- Severe comorbidities such as immunodeficiency
- Intravenous antibiotic therapy for more than 24 hours before oral antibiotics
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rigshospitalet
Copenhagen Ø, Denmark, 2100
Actively Recruiting
Research Team
U
Ulrikka Nygaard, Ass Professor, PhD, MD, MPhil
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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