Actively Recruiting
The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments
Led by Ottawa Heart Institute Research Corporation · Updated on 2026-05-06
1208
Participants Needed
4
Research Sites
253 weeks
Total Duration
On this page
Sponsors
O
Ottawa Heart Institute Research Corporation
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The INITIATE Study is a randomized controlled trial that is testing an intervention designed to increase long-term abstinence among tobacco smokers seen in emergency departments (ED) and other high-volume hospital and community ambulatory care settings. The intervention includes a behavioural incentive and tailored follow-up support on long-term smoking abstinence, health, healthcare utilization, and cost. Tobacco-related illnesses cost the healthcare system millions each year. Quitting smoking improves smoking-related outcomes, like the onset or management of heart disease, stroke, lung diseases, and several cancers. There are approximately 16 million visits to Canadian EDs each year; an estimated 3-4 million of these involve smokers. Effective quit smoking interventions exist, but are underutilized. Few hospital EDs, community healthcare centers, and other inpatient and outpatient clinics in Canada offer tobacco-use interventions. In order for clinicians to offer quit smoking support, interventions need to be simple given the realities of these high-volume environments. Considering that stopping smoking improves health outcomes, that tobacco-use is an important cause of preventable ED use, and the volume of smokers, Canadian EDs and other high-volume hospital and community ambulatory care settings are a missed opportunity in the initiation of quit smoking support. Our intervention has been designed to optimize uptake and smoking abstinence by including the most effective evidence-based behavioural and drug-related approaches, removing specific barriers and challenges that smokers face when trying to quit (e.g., affordability, low confidence and motivation), while packaging the intervention in a quick-to-initiate manner, making it ideal for fast-paced, complex environments.
CONDITIONS
Official Title
The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Current daily smoker (smokes 65 5 cigarettes per day)
- At least 18 years old
- For emergency department (ED) sites, assigned CTAS level of 2 to 5 (emergent to non-urgent)
- Able to read and understand English or French
- Resides in Ontario and eligible for Ontario Health Insurance Plan
- Available and willing to participate in follow-up assessments over 12 months
- Has access to a telephone or computer
- Able to provide informed consent
You will not qualify if you...
- Currently participating in this or another smoking cessation study
- For ED sites, assigned CTAS level of 1 (resuscitation) or in psychiatric emergency unit
- Pregnant, planning pregnancy in next year, or breastfeeding
- Has a serious illness preventing completion of 26-week follow-up (e.g., receiving palliative care)
- Acute physical or psychiatric illness or cognitive impairment preventing participation
- Scheduled for elective surgery, procedure, or hospitalization during study period
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 4 locations
1
Civic Hospital
Ottawa, Ontario, Canada
Actively Recruiting
2
General Hospital
Ottawa, Ontario, Canada
Actively Recruiting
3
Riverside Hospital
Ottawa, Ontario, Canada
Actively Recruiting
4
University of Ottawa Heart Institute
Ottawa, Ontario, Canada
Actively Recruiting
Research Team
C
Chantelle Masterson, BPhil
CONTACT
E
Evyanne Wooding, R.Kin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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