Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT04163081

The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments

Led by Ottawa Heart Institute Research Corporation · Updated on 2026-05-06

1208

Participants Needed

4

Research Sites

253 weeks

Total Duration

On this page

Sponsors

O

Ottawa Heart Institute Research Corporation

Lead Sponsor

C

Canadian Institutes of Health Research (CIHR)

Collaborating Sponsor

AI-Summary

What this Trial Is About

The INITIATE Study is a randomized controlled trial that is testing an intervention designed to increase long-term abstinence among tobacco smokers seen in emergency departments (ED) and other high-volume hospital and community ambulatory care settings. The intervention includes a behavioural incentive and tailored follow-up support on long-term smoking abstinence, health, healthcare utilization, and cost. Tobacco-related illnesses cost the healthcare system millions each year. Quitting smoking improves smoking-related outcomes, like the onset or management of heart disease, stroke, lung diseases, and several cancers. There are approximately 16 million visits to Canadian EDs each year; an estimated 3-4 million of these involve smokers. Effective quit smoking interventions exist, but are underutilized. Few hospital EDs, community healthcare centers, and other inpatient and outpatient clinics in Canada offer tobacco-use interventions. In order for clinicians to offer quit smoking support, interventions need to be simple given the realities of these high-volume environments. Considering that stopping smoking improves health outcomes, that tobacco-use is an important cause of preventable ED use, and the volume of smokers, Canadian EDs and other high-volume hospital and community ambulatory care settings are a missed opportunity in the initiation of quit smoking support. Our intervention has been designed to optimize uptake and smoking abstinence by including the most effective evidence-based behavioural and drug-related approaches, removing specific barriers and challenges that smokers face when trying to quit (e.g., affordability, low confidence and motivation), while packaging the intervention in a quick-to-initiate manner, making it ideal for fast-paced, complex environments.

CONDITIONS

Official Title

The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Current daily smoker (smokes 65 5 cigarettes per day)
  • At least 18 years old
  • For emergency department (ED) sites, assigned CTAS level of 2 to 5 (emergent to non-urgent)
  • Able to read and understand English or French
  • Resides in Ontario and eligible for Ontario Health Insurance Plan
  • Available and willing to participate in follow-up assessments over 12 months
  • Has access to a telephone or computer
  • Able to provide informed consent
Not Eligible

You will not qualify if you...

  • Currently participating in this or another smoking cessation study
  • For ED sites, assigned CTAS level of 1 (resuscitation) or in psychiatric emergency unit
  • Pregnant, planning pregnancy in next year, or breastfeeding
  • Has a serious illness preventing completion of 26-week follow-up (e.g., receiving palliative care)
  • Acute physical or psychiatric illness or cognitive impairment preventing participation
  • Scheduled for elective surgery, procedure, or hospitalization during study period

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 4 locations

1

Civic Hospital

Ottawa, Ontario, Canada

Actively Recruiting

2

General Hospital

Ottawa, Ontario, Canada

Actively Recruiting

3

Riverside Hospital

Ottawa, Ontario, Canada

Actively Recruiting

4

University of Ottawa Heart Institute

Ottawa, Ontario, Canada

Actively Recruiting

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Research Team

C

Chantelle Masterson, BPhil

CONTACT

E

Evyanne Wooding, R.Kin

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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