Studying Botulinum Toxin Injections for Treating Thumb Joint Arthritis Pain A Phase 3 Randomized Trial Comparing Botox to Standard Steroid Injections

What this Trial Is About

Researchers are evaluating the use of botulinum toxin injections as a potential alternative treatment for thumb carpometacarpal CMC osteoarthritis, a common cause of thumb joint pain. This study compares botulinum toxin injections to the standard corticosteroid injections, which are commonly used but have limited effectiveness and notable side effects. The trial aims to gather information on the safety and effectiveness of botulinum toxin for reducing thumb joint pain and arthritis symptoms. Participants will be randomly assigned to receive either the standard corticosteroid injection or a botulinum toxin injection directly into the thumb CMC joint. The botulinum toxin works differently from steroids by temporarily affecting nerve signals and reducing pain mediators. The study includes follow-up at several time points to assess the effects of the injections over time. Throughout the study, participants will have their thumb pain measured using a visual analog scale VAS at 2 weeks, 1 month, 6 months, and 1 year after injection. In addition, grip strength and thumb range of motion will be evaluated at these same visits. The study involves monitoring for safety and effectiveness over this one-year period to better understand how botulinum toxin may help manage thumb CMC osteoarthritis pain.

Injection of Botulinum Toxin for Thumb Carpometacarpal Arthritis