Monitoring Innate Immune Response by Monocyte HLA-DR in Adults Undergoing Surgery for Severe Intra-abdominal Infections to Assess Risk of Fungal Infection

What this Trial Is About

Researchers are studying intra-abdominal candidiasis IAC, a serious fungal infection often found in critically ill patients. This observational study aims to understand why some patients develop invasive IAC while others only have harmless colonization. It focuses on the role of innate immunity, specifically measuring monocyte HLA-DR expression, which may be reduced in patients who develop IAC compared to those with severe bacterial infections in the abdomen. The study involves monitoring patients with severe intra-abdominal infections, divided into two groups those with IAC and those with bacterial intra-abdominal infections without fungal involvement. Researchers analyze immune markers like monocyte HLA-DR expression and CD4 T lymphocyte counts. These assessments are done to compare immune function between the groups and better understand immune dysfunction related to fungal infection risk. Participants are patients admitted to intensive or intermediate care units for severe intra-abdominal infections requiring urgent surgery. Immune markers are measured from the day of surgery through seven days post-surgery. Researchers also track changes in immune cell populations, the impact of immune dysfunction on hospital outcomes up to 28 days, and correlate immune status with infection occurrence. The study helps improve early identification of patients at risk for invasive candidiasis and lasts from surgery through hospital stay with close immune monitoring.

Innate Immune Response Monitoring Via Monocyte HLA-DR in Severe Intra-abdominal Infections at Risk of Fungal Infection