Actively Recruiting
An Innovative Master Platform for Clinical Trials in Mood Disorders
Led by St. Joseph's Healthcare Hamilton · Updated on 2026-01-22
900
Participants Needed
9
Research Sites
128 weeks
Total Duration
On this page
Sponsors
S
St. Joseph's Healthcare Hamilton
Lead Sponsor
U
Unity Health Toronto
Collaborating Sponsor
AI-Summary
What this Trial Is About
Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person. Repeated efforts to find the right treatment contribute to poor functioning, low quality of life, and prolongs the time it takes to get well. Most areas of medicine are able to use 'biomarkers' or clinical tests, blood tests, or imaging to help diagnose and treat illness. The search for biomarkers in mood disorders is advancing, but one roadblock to progress is the lack of large, standardized studies of mood disorders that are needed to accurately identify biomarkers. The aim of the ENABLE platform is to provide the Canadian neuroscience community a standardized way of collecting biomarker data from individuals with a range of mood disorders symptoms. In addition, this 'master clinical trial platform' framework will provide a pool of participants who can be recruited into biomarker-based clinical trials.
CONDITIONS
Official Title
An Innovative Master Platform for Clinical Trials in Mood Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 16 years of age or older
- Meet criteria for bipolar or depressive disorders as defined by DSM-5
- Fluent in English to complete interviews and self-report questionnaires
- Healthy comparison participants must have no history of psychiatric disorders or significant unstable medical conditions
- Healthy comparison participants must be fluent in English to complete interviews and questionnaires
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
University of Calgary
Calgary, Alberta, Canada, T2N 4Z6
Actively Recruiting
2
University of British Columbia
Vancouver, British Columbia, Canada, V6T 2A1
Actively Recruiting
3
Nova Scotia Health Authority
Halifax, Nova Scotia, Canada, B3H 2E2
Actively Recruiting
4
McMaster University
Hamilton, Ontario, Canada, L8P 3B6
Actively Recruiting
5
Queen's University
Kingston, Ontario, Canada, K7L4X3
Actively Recruiting
6
University of Ottawa
Ottawa, Ontario, Canada, K1Z 7K4
Actively Recruiting
7
University Health Network
Toronto, Ontario, Canada, M5T 2S8
Actively Recruiting
8
Centre for Addiction and Mental Health
Toronto, Ontario, Canada, M6J 1H4
Actively Recruiting
9
Ontario Shores Centre for Mental Health Sciences
Whitby, Ontario, Canada, L1N 5S9
Actively Recruiting
Research Team
S
Saba Khoshroo
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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