Actively Recruiting
Innovative Steroid Treatment to Reduce Asthma Development in Children After First-time Rhinovirus Induced Wheezing
Led by St. Olavs Hospital · Updated on 2025-06-13
280
Participants Needed
8
Research Sites
468 weeks
Total Duration
On this page
Sponsors
S
St. Olavs Hospital
Lead Sponsor
T
Turku University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The overall objective of the study is to determine the efficacy of corticosteroids in preventing recurrent wheezing and asthma in high-risk, first-time severe wheezing children with rhinovirus infection, stratified by rhinovirus genome load. The secondary objectives are to determine duration and severity of each acute episode with acute expiratory breathing difficulty, the number of episodes with acute expiratory breathing difficulty, degree of pulmonary hyperreactivity and quality of life within 24 months after study entry.
CONDITIONS
Official Title
Innovative Steroid Treatment to Reduce Asthma Development in Children After First-time Rhinovirus Induced Wheezing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Admitted to pediatric acute wards in participating hospitals in Norway, Finland, Sweden
- Referred for first severe wheezing episode with acute breathing difficulty and wheezing lasting less than 7 days
- One or more of the following symptoms: fever, oxygen saturation ≤ 92%, chest retractions, prolonged expiration, or expiratory rhonchi
- Rhinovirus infection confirmed by PCR test in nasopharyngeal secretions
- Signed informed consent and expected cooperation for treatment and follow-up according to regulations
You will not qualify if you...
- Previous wheezing episodes needing treatment or similar breathing difficulties reported by parents
- Born before 37 weeks of gestation
- Chronic illness other than eczema
- Previous systemic or inhaled corticosteroid treatment
- Participation in another clinical trial
- Varicella infection or contact in the last 2-3 weeks
- Need for intensive care unit treatment during current infection, except non-invasive respiratory support
- Any reason investigator considers the patient unsuitable, such as inability to comply with procedures
- COVID-19 related disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Turku University Hospital
Turku, Finland
Actively Recruiting
2
Haukeland University Hospital
Bergen, Norway
Actively Recruiting
3
Akershus University Hospital
Oslo, Norway
Actively Recruiting
4
Ullevål University Hospital
Oslo, Norway
Actively Recruiting
5
Stavanger University Hospital
Stavanger, Norway
Actively Recruiting
6
University Hospital of North Norway
Tromsø, Norway
Actively Recruiting
7
St Olavs Hospital
Trondheim, Norway
Actively Recruiting
8
Karolinska Universitetssjukhuset
Stockholm, Sweden
Actively Recruiting
Research Team
H
Henrik Døllner, md phd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here