Actively Recruiting
INOCA-NA a Local Prospective Registry
Led by Federico II University · Updated on 2025-03-17
250
Participants Needed
1
Research Sites
153 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The present study has the following objectives: 1. To investigate the prevalence of INOCA in patients referring for a clinically indicated coronary angiography (CA) c/o Division of Cardiology - Federico II University Hospital; 2. To stratify in INOCA endotypes patients according to the presence or absence of alternative (i.e. non obstructive CAD) causes of myocardial ischemia detected during CA clinically indicated through physiology tests; 3. to implement a stratified therapy in these patients considering the different INOCA endotypes and evaluate the impact on angina class and quality of life as well as cardiac hospitalization and coronary revascularization during 5 year follow up
CONDITIONS
Official Title
INOCA-NA a Local Prospective Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical presentation of chronic ischemic heart disease requiring coronary angiography for diagnosis
- No obstructive coronary artery disease found at coronary angiography
- Age over 18 years
- Ability to provide valid informed consent at baseline evaluation
You will not qualify if you...
- Acute coronary syndrome or cardiogenic shock
- Presence of obstructive coronary artery disease with at least 1 significant stenosis (diameter stenosis >50% and FFR 6440.80 or iFR/RFR 6440.89)
- Previous coronary artery bypass grafting (CABG)
- Left ventricular systolic dysfunction with ejection fraction <40%
- Severe valvular heart disease
- Pregnant or breastfeeding women
- Known hypersensitivity or contraindication to drugs used for coronary physiology testing (adenosine, nitrates, acetylcholine)
- Inability or unwillingness to provide valid informed consent at baseline evaluation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
DPT of Advanced Biomedical Sciences
Naples, Italy, Italy, 80131
Actively Recruiting
Research Team
L
Luigi Di Serafino, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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