Inorganic Nitrate Supplementation for Blood Pressure Control in Chronic Hypertensive Pregnancies From the 2nd Trimester (NIT_CH) A Triple-Blind Randomized Placebo-Controlled Trial

What this Trial Is About

High blood pressure during pregnancy can pose serious risks to both mother and baby. This research aims to explore whether inorganic nitrate supplementation, which may help relax and widen blood vessels, can improve blood pressure control in pregnant women with chronic hypertension. Preliminary studies in animals and small groups of pregnant women have shown promising results, motivating this detailed investigation starting in the second trimester. Participants will be randomly assigned to receive either a daily capsule containing inorganic nitrate or a placebo, starting from the 16th week of pregnancy and continuing for 22 weeks or until delivery. All participants will continue standard medication for preeclampsia prevention, including low-dose aspirin and calcium carbonate, as well as their regular blood pressure treatments. The study uses a triple-blind design, and capsules for both groups look identical. During the study, participants will attend regular visits roughly every 4 weeks initially, increasing in frequency as delivery approaches. At these visits, they will undergo clinical exams, blood pressure checks, blood and urine tests, and ultrasound with Doppler studies of uterine arteries. Medication adjustments will be made as needed to maintain proper blood pressure. Researchers will monitor various health markers and pregnancy outcomes from the 16th week until delivery, ensuring close follow-up throughout the pregnancy period.

Inorganic Nitrate Supplementation in Chronic Hypertensive Pregnancies