Actively Recruiting
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy
Led by Children's Oncology Group · Updated on 2026-05-05
5951
Participants Needed
230
Research Sites
647 weeks
Total Duration
On this page
Sponsors
C
Children's Oncology Group
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy and immunotherapy (chemo-immunotherapy) for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. Inotuzumab ozogamicin is a monoclonal antibody, which is a type of protein that can bind to certain targets on the surface of cells. Inotuzumab ozogamicin is a monoclonal antibody that is linked to a type of chemotherapy called calicheamicin. Inotuzumab attaches to cancer cells by binding to the CD22 protein on the surface of the cancer cell and delivering calicheamicin inside the cells to kill them. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, and pegaspargase or calaspargase pegol work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Blinatumomab is a specialized type of monoclonal antibody known as a bispecific T-cell engager (BiTE). It works by simultaneously binding to CD19 on cancer cells and CD3 on normal immune cells, bringing them together to destroy leukemia cells. Blinatumomab is a standard part of chemo-immunotherapy treatment for B-ALL. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with ALL therapy without inotuzumab ozogamicin or blinatumomab. The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemo-immunotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). The first part of the study includes the first phase of therapy: Induction. This part will collect information on the leukemia, as well as the effects of the initial treatment, to classify patients into post-induction treatment groups. On the second part of this study, patients with HR B-ALL will receive the remainder of the chemotherapy cycles (consolidation, blinatumomab block 1, interim maintenance 1, blinatumomab block 2, delayed intensification, interim maintenance 2, maintenance), with some patients randomized to receive inotuzumab. The patients that receive inotuzumab will not receive part of consolidation or part of delayed intensification. Other aims of this study include evaluating 1) side effects of treatment using patient-reported outcomes and health-related quality of life, 2) the best ways to help patients adhere to oral chemotherapy regimens, 3) the relationship between levels of inotuzumab ozogamicin in the blood and side effects, 4) the impact of chemo-immunotherapy on the immune system and risk of infection, and 5) the impact of social determinants of health on outcomes. Finally, this study will be the first to track the outcomes of subjects with disseminated B-cell Lymphoblastic Leukemia (B-LLy) or Mixed Phenotype Acute Leukemia (MPAL) when treated with B-ALL chemotherapy.
CONDITIONS
Official Title
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must be more than 365 days and less than 25 years old
- Patients with B-ALL and MPAL must be enrolled on APEC14B1 and consent to eligibility studies before treatment and enrollment
- Central confirmation of MPAL diagnosis must occur within 22 days of enrollment for suspected MPAL patients
- B-LLy patients may enroll directly and should be offered participation in APEC14B1
- Newly diagnosed B-ALL or MPAL patients must have 25% or more blasts on bone marrow aspirate or a diagnostic bone marrow biopsy, or at least 1,000 leukemic cells per microliter in blood if bone marrow cannot be performed
- Newly diagnosed B-LLy patients with Murphy stage III or IV, or stages I or II with steroid pretreatment
- Central nervous system status must be determined before enrollment
- All patients and/or guardians must provide written informed consent
- All regulatory requirements must be met
You will not qualify if you...
- Patients with Down syndrome
- Patients who received prior cytotoxic chemotherapy for current diagnosis except steroid pretreatment or intrathecal cytarabine
- Patients who received more than 72 hours of hydroxyurea within one week before starting protocol therapy
- Patients with insufficient diagnostic bone marrow or peripheral blood samples for testing
- Patients with acute undifferentiated leukemia
- For B-LLy patients: T-lymphoblastic lymphoma, unclassifiable lymphoma, or absence of both B- and T-cell markers
- Patients with Charcot-Marie-Tooth disease
- Patients with MYC translocation associated with mature Burkitt B-cell ALL
- Patients requiring radiation at diagnosis
- Female patients who are pregnant
- Lactating women planning to breastfeed during the study and for 2 months after last dose of inotuzumab ozogamicin
- Sexually active patients who do not agree to use effective contraception during participation and for specified months after last dose of inotuzumab ozogamicin
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 230 locations
1
Children's Hospital of Alabama
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
USA Health Strada Patient Care Center
Mobile, Alabama, United States, 36604
Actively Recruiting
3
Providence Alaska Medical Center
Anchorage, Alaska, United States, 99508
Actively Recruiting
4
Banner Children's at Desert
Mesa, Arizona, United States, 85202
Actively Recruiting
5
Phoenix Childrens Hospital
Phoenix, Arizona, United States, 85016
Actively Recruiting
6
Banner University Medical Center - Tucson
Tucson, Arizona, United States, 85719
Actively Recruiting
7
Arkansas Children's Hospital
Little Rock, Arkansas, United States, 72202-3591
Actively Recruiting
8
Kaiser Permanente Downey Medical Center
Downey, California, United States, 90242
Actively Recruiting
9
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010
Actively Recruiting
10
Loma Linda University Medical Center
Loma Linda, California, United States, 92354
Actively Recruiting
11
Miller Children's and Women's Hospital Long Beach
Long Beach, California, United States, 90806
Actively Recruiting
12
Children's Hospital Los Angeles
Los Angeles, California, United States, 90027
Actively Recruiting
13
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
14
Mattel Children's Hospital UCLA
Los Angeles, California, United States, 90095
Suspended
15
Valley Children's Hospital
Madera, California, United States, 93636
Actively Recruiting
16
UCSF Benioff Children's Hospital Oakland
Oakland, California, United States, 94609
Actively Recruiting
17
Kaiser Permanente-Oakland
Oakland, California, United States, 94611
Actively Recruiting
18
Children's Hospital of Orange County
Orange, California, United States, 92868
Actively Recruiting
19
Lucile Packard Children's Hospital Stanford University
Palo Alto, California, United States, 94304
Actively Recruiting
20
Sutter Medical Center Sacramento
Sacramento, California, United States, 95816
Actively Recruiting
21
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States, 95817
Actively Recruiting
22
Rady Children's Hospital - San Diego
San Diego, California, United States, 92123
Actively Recruiting
23
Naval Medical Center -San Diego
San Diego, California, United States, 92134
Actively Recruiting
24
UCSF Medical Center-Mission Bay
San Francisco, California, United States, 94158
Actively Recruiting
25
Santa Barbara Cottage Hospital
Santa Barbara, California, United States, 93102
Actively Recruiting
26
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, United States, 90502
Active, Not Recruiting
27
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
28
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver, Colorado, United States, 80218
Actively Recruiting
29
Connecticut Children's Medical Center
Hartford, Connecticut, United States, 06106
Actively Recruiting
30
Yale University
New Haven, Connecticut, United States, 06520
Actively Recruiting
31
Alfred I duPont Hospital for Children
Wilmington, Delaware, United States, 19803
Actively Recruiting
32
MedStar Georgetown University Hospital
Washington D.C., District of Columbia, United States, 20007
Suspended
33
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
34
Broward Health Medical Center
Fort Lauderdale, Florida, United States, 33316
Actively Recruiting
35
Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida, United States, 33908
Actively Recruiting
36
UF Health Cancer Institute - Gainesville
Gainesville, Florida, United States, 32610
Actively Recruiting
37
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida, United States, 33021
Actively Recruiting
38
Nemours Children's Clinic-Jacksonville
Jacksonville, Florida, United States, 32207
Actively Recruiting
39
Palms West Radiation Therapy
Loxahatchee Groves, Florida, United States, 33470
Active, Not Recruiting
40
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States, 33136
Actively Recruiting
41
Nicklaus Children's Hospital
Miami, Florida, United States, 33155
Actively Recruiting
42
Miami Cancer Institute
Miami, Florida, United States, 33176
Active, Not Recruiting
43
AdventHealth Orlando
Orlando, Florida, United States, 32803
Actively Recruiting
44
Arnold Palmer Hospital for Children
Orlando, Florida, United States, 32806
Actively Recruiting
45
Nemours Children's Hospital
Orlando, Florida, United States, 32827
Actively Recruiting
46
Nemours Children's Clinic - Pensacola
Pensacola, Florida, United States, 32504
Actively Recruiting
47
Sacred Heart Hospital
Pensacola, Florida, United States, 32504
Suspended
48
Johns Hopkins All Children's Hospital
St. Petersburg, Florida, United States, 33701
Actively Recruiting
49
Tampa General Hospital
Tampa, Florida, United States, 33606
Actively Recruiting
50
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida, United States, 33607
Actively Recruiting
51
Saint Mary's Medical Center
West Palm Beach, Florida, United States, 33407
Actively Recruiting
52
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, United States, 30329
Actively Recruiting
53
Augusta University Medical Center
Augusta, Georgia, United States, 30912
Actively Recruiting
54
Atrium Health Navicent
Macon, Georgia, United States, 31201
Actively Recruiting
55
Memorial Health University Medical Center
Savannah, Georgia, United States, 31404
Actively Recruiting
56
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, United States, 96826
Actively Recruiting
57
Saint Luke's Cancer Institute - Boise
Boise, Idaho, United States, 83712
Actively Recruiting
58
Lurie Children's Hospital-Chicago
Chicago, Illinois, United States, 60611
Actively Recruiting
59
University of Illinois
Chicago, Illinois, United States, 60612
Actively Recruiting
60
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States, 60637
Actively Recruiting
61
Loyola University Medical Center
Maywood, Illinois, United States, 60153
Actively Recruiting
62
Advocate Children's Hospital-Oak Lawn
Oak Lawn, Illinois, United States, 60453
Actively Recruiting
63
Advocate Children's Hospital-Park Ridge
Park Ridge, Illinois, United States, 60068
Actively Recruiting
64
Saint Jude Midwest Affiliate
Peoria, Illinois, United States, 61637
Actively Recruiting
65
Southern Illinois University School of Medicine
Springfield, Illinois, United States, 62702
Suspended
66
Northwestern Medicine Central DuPage Hospital
Winfield, Illinois, United States, 60190
Actively Recruiting
67
Riley Hospital for Children
Indianapolis, Indiana, United States, 46202
Actively Recruiting
68
Ascension Saint Vincent Indianapolis Hospital
Indianapolis, Indiana, United States, 46260
Actively Recruiting
69
Blank Children's Hospital
Des Moines, Iowa, United States, 50309
Actively Recruiting
70
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, United States, 52242
Actively Recruiting
71
Wesley Medical Center
Wichita, Kansas, United States, 67214
Actively Recruiting
72
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, United States, 40536
Actively Recruiting
73
Norton Children's Hospital
Louisville, Kentucky, United States, 40202
Actively Recruiting
74
Children's Hospital New Orleans
New Orleans, Louisiana, United States, 70118
Actively Recruiting
75
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States, 70121
Actively Recruiting
76
Eastern Maine Medical Center
Bangor, Maine, United States, 04401
Actively Recruiting
77
Maine Children's Cancer Program
Scarborough, Maine, United States, 04074
Actively Recruiting
78
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, United States, 21201
Actively Recruiting
79
Sinai Hospital of Baltimore
Baltimore, Maryland, United States, 21215
Actively Recruiting
80
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, United States, 21287
Actively Recruiting
81
Walter Reed National Military Medical Center
Bethesda, Maryland, United States, 20889-5600
Actively Recruiting
82
Tufts Children's Hospital
Boston, Massachusetts, United States, 02111
Active, Not Recruiting
83
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, United States, 02114
Actively Recruiting
84
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
85
Baystate Medical Center
Springfield, Massachusetts, United States, 01199
Actively Recruiting
86
UMass Memorial Medical Center - University Campus
Worcester, Massachusetts, United States, 01655
Actively Recruiting
87
C S Mott Children's Hospital
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
88
Children's Hospital of Michigan
Detroit, Michigan, United States, 48201
Actively Recruiting
89
Henry Ford Health Saint John Hospital
Detroit, Michigan, United States, 48236
Active, Not Recruiting
90
Michigan State University
East Lansing, Michigan, United States, 48823
Active, Not Recruiting
91
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
92
Bronson Methodist Hospital
Kalamazoo, Michigan, United States, 49007
Actively Recruiting
93
Corewell Health Children's
Royal Oak, Michigan, United States, 48073
Actively Recruiting
94
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis, Minnesota, United States, 55404
Actively Recruiting
95
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
96
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
97
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Actively Recruiting
98
University of Missouri Children's Hospital
Columbia, Missouri, United States, 65212
Actively Recruiting
99
Children's Mercy Hospitals and Clinics
Kansas City, Missouri, United States, 64108
Actively Recruiting
100
Cardinal Glennon Children's Medical Center
St Louis, Missouri, United States, 63104
Actively Recruiting
101
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
102
Mercy Hospital Saint Louis
St Louis, Missouri, United States, 63141
Actively Recruiting
103
Children's Hospital and Medical Center of Omaha
Omaha, Nebraska, United States, 68114
Actively Recruiting
104
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
105
University Medical Center of Southern Nevada
Las Vegas, Nevada, United States, 89102
Suspended
106
Sunrise Hospital and Medical Center
Las Vegas, Nevada, United States, 89109
Suspended
107
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, United States, 89135
Actively Recruiting
108
Summerlin Hospital Medical Center
Las Vegas, Nevada, United States, 89144
Actively Recruiting
109
Renown Regional Medical Center
Reno, Nevada, United States, 89502
Actively Recruiting
110
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
111
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
112
Morristown Medical Center
Morristown, New Jersey, United States, 07960
Actively Recruiting
113
Jersey Shore Medical Center
Neptune City, New Jersey, United States, 07753
Actively Recruiting
114
Saint Peter's University Hospital
New Brunswick, New Jersey, United States, 08901
Actively Recruiting
115
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick, New Jersey, United States, 08903
Actively Recruiting
116
Newark Beth Israel Medical Center
Newark, New Jersey, United States, 07112
Actively Recruiting
117
Saint Joseph's Regional Medical Center
Paterson, New Jersey, United States, 07503
Actively Recruiting
118
Presbyterian Hospital
Albuquerque, New Mexico, United States, 87106
Actively Recruiting
119
University of New Mexico Cancer Center
Albuquerque, New Mexico, United States, 87106
Actively Recruiting
120
Albany Medical Center
Albany, New York, United States, 12208
Actively Recruiting
121
Maimonides Medical Center
Brooklyn, New York, United States, 11219
Actively Recruiting
122
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
Actively Recruiting
123
NYU Langone Hospital - Long Island
Mineola, New York, United States, 11501
Actively Recruiting
124
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park, New York, United States, 11040
Actively Recruiting
125
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, United States, 10016
Actively Recruiting
126
Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
127
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, United States, 10032
Actively Recruiting
128
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
129
NYP/Weill Cornell Medical Center
New York, New York, United States, 10065
Actively Recruiting
130
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
131
Stony Brook University Medical Center
Stony Brook, New York, United States, 11794
Actively Recruiting
132
State University of New York Upstate Medical University
Syracuse, New York, United States, 13210
Actively Recruiting
133
Montefiore Medical Center - Moses Campus
The Bronx, New York, United States, 10467
Actively Recruiting
134
New York Medical College
Valhalla, New York, United States, 10595
Actively Recruiting
135
Mission Hospital
Asheville, North Carolina, United States, 28801
Actively Recruiting
136
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
137
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, United States, 28203
Actively Recruiting
138
Novant Health Presbyterian Medical Center
Charlotte, North Carolina, United States, 28204
Actively Recruiting
139
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
140
East Carolina University
Greenville, North Carolina, United States, 27834
Actively Recruiting
141
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
142
Sanford Broadway Medical Center
Fargo, North Dakota, United States, 58122
Actively Recruiting
143
Children's Hospital Medical Center of Akron
Akron, Ohio, United States, 44308
Actively Recruiting
144
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
145
Rainbow Babies and Childrens Hospital
Cleveland, Ohio, United States, 44106
Actively Recruiting
146
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Actively Recruiting
147
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Actively Recruiting
148
Dayton Children's Hospital
Dayton, Ohio, United States, 45404
Actively Recruiting
149
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo, Ohio, United States, 43606
Actively Recruiting
150
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
151
Natalie Warren Bryant Cancer Center at Saint Francis
Tulsa, Oklahoma, United States, 74136
Actively Recruiting
152
Legacy Emanuel Children's Hospital
Portland, Oregon, United States, 97227
Actively Recruiting
153
Oregon Health and Science University
Portland, Oregon, United States, 97239
Actively Recruiting
154
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, United States, 18103
Actively Recruiting
155
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822
Actively Recruiting
156
Penn State Children's Hospital
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
157
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
158
Saint Christopher's Hospital for Children
Philadelphia, Pennsylvania, United States, 19134
Actively Recruiting
159
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
160
Rhode Island Hospital
Providence, Rhode Island, United States, 02903
Actively Recruiting
161
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
162
Prisma Health Richland Hospital
Columbia, South Carolina, United States, 29203
Actively Recruiting
163
BI-LO Charities Children's Cancer Center
Greenville, South Carolina, United States, 29605
Actively Recruiting
164
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, United States, 57117-5134
Actively Recruiting
165
T C Thompson Children's Hospital
Chattanooga, Tennessee, United States, 37403
Actively Recruiting
166
East Tennessee Childrens Hospital
Knoxville, Tennessee, United States, 37916
Actively Recruiting
167
The Children's Hospital at TriStar Centennial
Nashville, Tennessee, United States, 37203
Actively Recruiting
168
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
169
Texas Tech University Health Sciences Center-Amarillo
Amarillo, Texas, United States, 79106
Actively Recruiting
170
Dell Children's Medical Center of Central Texas
Austin, Texas, United States, 78723
Actively Recruiting
171
Driscoll Children's Hospital
Corpus Christi, Texas, United States, 78411
Actively Recruiting
172
Medical City Dallas Hospital
Dallas, Texas, United States, 75230
Actively Recruiting
173
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, United States, 75390
Actively Recruiting
174
El Paso Children's Hospital
El Paso, Texas, United States, 79905
Actively Recruiting
175
Cook Children's Medical Center
Fort Worth, Texas, United States, 76104
Actively Recruiting
176
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
177
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
178
Covenant Children's Hospital
Lubbock, Texas, United States, 79410
Actively Recruiting
179
UMC Cancer Center / UMC Health System
Lubbock, Texas, United States, 79415
Actively Recruiting
180
Vannie Cook Children's Clinic
McAllen, Texas, United States, 78503
Actively Recruiting
181
Children's Hospital of San Antonio
San Antonio, Texas, United States, 78207
Actively Recruiting
182
Methodist Children's Hospital of South Texas
San Antonio, Texas, United States, 78229
Actively Recruiting
183
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
184
Scott and White Memorial Hospital
Temple, Texas, United States, 76508
Actively Recruiting
185
Primary Children's Hospital
Salt Lake City, Utah, United States, 84113
Actively Recruiting
186
University of Vermont and State Agricultural College
Burlington, Vermont, United States, 05405
Actively Recruiting
187
University of Virginia Cancer Center
Charlottesville, Virginia, United States, 22908
Actively Recruiting
188
Inova Fairfax Hospital
Falls Church, Virginia, United States, 22042
Actively Recruiting
189
Children's Hospital of The King's Daughters
Norfolk, Virginia, United States, 23507
Actively Recruiting
190
Naval Medical Center - Portsmouth
Portsmouth, Virginia, United States, 23708-2197
Actively Recruiting
191
VCU Massey Comprehensive Cancer Center
Richmond, Virginia, United States, 23298
Actively Recruiting
192
Carilion Children's
Roanoke, Virginia, United States, 24014
Actively Recruiting
193
Seattle Children's Hospital
Seattle, Washington, United States, 98105
Actively Recruiting
194
Providence Sacred Heart Medical Center and Children's Hospital
Spokane, Washington, United States, 99204
Actively Recruiting
195
Mary Bridge Children's Hospital and Health Center
Tacoma, Washington, United States, 98405
Actively Recruiting
196
Madigan Army Medical Center
Tacoma, Washington, United States, 98431
Suspended
197
West Virginia University Charleston Division
Charleston, West Virginia, United States, 25304
Actively Recruiting
198
Edwards Comprehensive Cancer Center
Huntington, West Virginia, United States, 25701
Suspended
199
West Virginia University Healthcare
Morgantown, West Virginia, United States, 26506
Suspended
200
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, United States, 54301
Actively Recruiting
201
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, United States, 53792
Actively Recruiting
202
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, United States, 54449
Actively Recruiting
203
Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
204
John Hunter Children's Hospital
Hunter Regional Mail Centre, New South Wales, Australia, 2310
Suspended
205
The Children's Hospital at Westmead
Westmead, New South Wales, Australia, 2145
Suspended
206
Queensland Children's Hospital
South Brisbane, Queensland, Australia, 4101
Suspended
207
Women's and Children's Hospital-Adelaide
North Adelaide, South Australia, Australia, 5006
Suspended
208
Monash Medical Center-Clayton Campus
Clayton, Victoria, Australia, 3168
Suspended
209
Royal Children's Hospital
Parkville, Victoria, Australia, 3052
Suspended
210
Perth Children's Hospital
Perth, Western Australia, Australia, 6009
Suspended
211
Alberta Children's Hospital
Calgary, Alberta, Canada, T3B 6A8
Actively Recruiting
212
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
213
British Columbia Children's Hospital
Vancouver, British Columbia, Canada, V6H 3V4
Actively Recruiting
214
CancerCare Manitoba
Winnipeg, Manitoba, Canada, R3E 0V9
Suspended
215
Janeway Child Health Centre
St. John's, Newfoundland and Labrador, Canada, A1B 3V6
Actively Recruiting
216
IWK Health Centre
Halifax, Nova Scotia, Canada, B3K 6R8
Actively Recruiting
217
McMaster Children's Hospital at Hamilton Health Sciences
Hamilton, Ontario, Canada, L8N 3Z5
Actively Recruiting
218
Kingston Health Sciences Centre
Kingston, Ontario, Canada, K7L 2V7
Actively Recruiting
219
Children's Hospital
London, Ontario, Canada, N6A 5W9
Actively Recruiting
220
Children's Hospital of Eastern Ontario
Ottawa, Ontario, Canada, K1H 8L1
Actively Recruiting
221
Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8
Suspended
222
The Montreal Children's Hospital of the MUHC
Montreal, Quebec, Canada, H3H 1P3
Suspended
223
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, Canada, J1H 5N4
Suspended
224
Jim Pattison Children's Hospital
Saskatoon, Saskatchewan, Canada, S7N 0W8
Actively Recruiting
225
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada, S7N 4H4
Suspended
226
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
Québec, Canada, G1V 4G2
Suspended
227
Starship Children's Hospital
Grafton, Auckland, New Zealand, 1145
Actively Recruiting
228
Christchurch Hospital
Christchurch, New Zealand, 8011
Actively Recruiting
229
HIMA San Pablo Oncologic Hospital
Caguas, Puerto Rico, 00726
Active, Not Recruiting
230
University Pediatric Hospital
San Juan, Puerto Rico, 00926
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here