Actively Recruiting
INPWT on Wound Complications & Clinical Outcomes After Lower Extremity Sarcoma Surgery Preop Radiation Therapy Patients
Led by Dr. J. Werier · Updated on 2026-03-02
291
Participants Needed
2
Research Sites
312 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Project Summary - Aggressive soft tissue cancers are commonly treated with radiation followed by surgery. These wounds have a very high rate of wound complications and infection (30%), resulting in more surgeries, longer hospital stays and complex nursing care. Previous research shows that negative pressure (vacuum) dressings applied to the incision at the end of surgery can reduce these complications. The Investigator and his team across Canada will perform a clinical trial comparing standard dressings to these vacuum dressings. The results of this study have the potential to immediately improve the quality of life of soft tissue cancer patients. It can also decrease the amount of time required in hospital and reduce the cost to the Canadian healthcare system.
CONDITIONS
Official Title
INPWT on Wound Complications & Clinical Outcomes After Lower Extremity Sarcoma Surgery Preop Radiation Therapy Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years of age and older and able to provide written consent.
- Diagnosis of lower extremity soft tissue sarcoma confirmed by tissue pathology.
- Local cross sectional imaging (CT or MRI) and staging CT chest completed.
- Eligible for preoperative radiation therapy followed by limb salvage surgery.
- Primary closure must be attainable at the time of surgery.
- Available for postoperative follow-up at the treating center.
You will not qualify if you...
- Patients younger than 18 years.
- Diagnosis of benign disease or prior radiation to the anatomic region unrelated to current treatment.
- Patients who underwent surgical amputation.
- Primary closure not achieved (including free flaps and split thickness skin grafts).
- Life expectancy less than 120 days.
- Allergy or sensitivity to adhesive dressings.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
The Ottawa Hospital
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
2
McGill University Health Center
Montreal, Quebec, Canada
Actively Recruiting
Research Team
Y
Yusra K Al-Mosuli
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here