Controlled Multicenter Study of Peripheral Immune Cells and Microbiota in Idiopathic Nephrotic Syndrome Patients

What this Trial Is About

Researchers are studying idiopathic nephrotic syndrome INS, a kidney condition marked by protein loss in urine, low blood protein levels, and specific kidney tissue changes. The cause of INS is unknown, but immune system involvement is suspected, including links with allergies, diet, and gut bacteria imbalance. The study explores how immune cells and microbiota may relate to INS and its recurrence after kidney transplantation. This observational study collects blood, urine, and feces samples from patients with nephrotic syndrome to analyze their immune cell populations and microbiota composition using advanced sequencing methods. Participants include those with idiopathic nephrotic syndrome and others with non-idiopathic nephrotic syndromes for comparison. Samples are taken at the start and again after three months to track changes over time. Participants will provide blood, urine, and stool samples during two visits three months apart without any changes to their usual treatment. Researchers will examine the immune cells and microbiota in these samples to understand differences between idiopathic and non-idiopathic nephrotic syndrome patients. The primary outcomes involve sequencing and analyzing the peripheral blood immune cells and intestinal and urinary microbiota, helping to uncover potential links between immune regulation, gut bacteria, and INS progression.

INS, B Cells and Microbiota