Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06526598

Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial

Led by Capital Medical University · Updated on 2026-01-21

619

Participants Needed

1

Research Sites

57 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The Inspiratory effort-Targeted Pressure Support Ventilation (IT-PSV) is a cluster randomized controlled trial. Its main aim is to determine whether an inspiratory effort-targeted pressure support setting strategy, compared to the traditional tidal volume and respiratory rate target, can improve clinical outcomes in adult participants undergoing pressure support ventilation. The investigators propose a physiological-oriented assisted ventilation management that, if found effective, could potentially change the clinical practice for mechanical ventilation.

CONDITIONS

Official Title

Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • PSV initiated during the last 24 hours
  • Mechanical ventilation expected to be required for at least 24-48 hours
  • Partial pressure of oxygen in arterial blood (PaO2) to inspired oxygen fraction (FiO2) ratio 300 mmHg
  • No sedation or stable sedation with Richmond Agitation Sedation Scale (RASS) of -2 to +1 or Riker's Sedation-Agitation Scale (SAS) of 3 to 4
Not Eligible

You will not qualify if you...

  • Younger than 18 years old
  • Initiation of PSV before ICU admission
  • Mechanical ventilation longer than 7 days before enrollment
  • History of neuromuscular diseases
  • Clinical suspicion of increased intracranial pressure
  • Receiving extracorporeal support
  • Moribund condition
  • Refusal by ICU physicians or the patient

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Beijing Shijitan Hospital

Beijing, Beijing Municipality, China, 100038

Actively Recruiting

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Research Team

J

Jian-Xin Zhou, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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