Actively Recruiting
Inspiratory Muscle Training in HFpEF
Led by Mayo Clinic · Updated on 2025-10-20
68
Participants Needed
1
Research Sites
181 weeks
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is being done to determine how inspiratory muscle training impacts inspiratory muscle function during exercise in heart failure patients.
CONDITIONS
Official Title
Inspiratory Muscle Training in HFpEF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Receiving SGLT2 inhibitors and spironolactone (and beta-blocker use for HFpEF patients with hypertension) for more than 3 months
- NYHA symptoms I-III
- Body mass index 40 kg/m2 or less
- Currently non-smokers with less than 20 pack-year smoking history
- Able to exercise without significant orthopedic or musculoskeletal limitations
You will not qualify if you...
- Ventricular tachycardia and/or ventricular fibrillation within 21 days of visit 1
- Second or third degree heart block
- Body mass index over 40 kg/m2
- Current smokers or smoking history over 20 pack years
- Pregnant women
- Glomerular filtration rate less than 30 mL/min/1.73m2
- Unable to engage in exercise
- Uremia or history of allergy to iodides
- Peripheral artery disease
- Alanine transaminase and/or aspartate transaminase levels greater than twice the upper limit of normal
- Asthmatic patients with low symptom perception or severe exacerbations
- Ruptured eardrum or other ear conditions
- History of spontaneous pneumothorax or osteoporosis with rib fractures
- History of lidocaine allergy
- Additional exclusions for DEXA scanning participants: recent gastrointestinal contrast or radionuclide administration, severe degenerative changes or fractures in measurement areas, or inability to remain motionless during measurement
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
E
Eric Bruhn, M.A.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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