Reducing Exercise Intolerance Through Inspiratory Muscle Training in Obese Breast Cancer Survivors

What this Trial Is About

Researchers are evaluating the effectiveness of inspiratory muscle training (IMT) in improving exercise tolerance among obese breast cancer survivors who have completed active treatment for stage 0 to III breast cancer. The study involves individuals with obesity, defined by a body mass index (BMI) of 30 to 50 kg/m2, and focuses on those who are sedentary and have some exercise intolerance. This randomized controlled trial aims to provide insights into how IMT combined with exercise may benefit this population. Participants are randomly assigned to one of two groups: one group receives 4 weeks of inspiratory muscle training using a pressure threshold device at up to 70% of maximal inspiratory pressure, performed three times per week with three sets of 15 repetitions. This is followed by 12 weeks of aerobic exercise training including activities like cycling, walking, and elliptical sessions three times per week for up to 50 minutes per session at moderate intensity. The second group receives 4 weeks of sham training at 10% of maximal inspiratory pressure with the same exercise program starting in week 5. The study is double-blinded to compare the effects of IMT plus exercise versus sham training plus exercise. During the 16-week study, participants undergo assessments at baseline, after 4 weeks, and at 16 weeks to measure changes in exercise tolerance, inspiratory muscle strength and endurance, exercise capacity, dyspnea, and fatigue. The study includes supervised exercise sessions and uses a pressure threshold device for training. Researchers monitor safety and adherence closely. The total participation involves 4 weeks of initial training followed by 12 weeks of aerobic exercise, with ongoing evaluation of physical function and symptoms related to breathing and fatigue.

Inspiratory Muscle Training in Obese Breast Cancer Survivors