Actively Recruiting
The INSPIRE Study: Intervention Strategies for Preserving Intellectual Resilience and Engagement
Led by Healthy Minds Initiative · Updated on 2025-08-21
2000
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
Sponsors
H
Healthy Minds Initiative
Lead Sponsor
A
American College of Lifestyle Medicine
Collaborating Sponsor
AI-Summary
What this Trial Is About
The INSPIRE Study, initiated by the Healthy Minds Initiative, is a community-based research project aimed at demonstrating the impact of lifestyle factors on cognitive health and the prevention of dementia. Conducted in collaboration with the American College of Lifestyle Medicine, Charles Drew University, UCLA, Stanford University and Crenshaw Christian Center, this study focuses on African American communities that are disproportionately affected by lifestyle-dependent diseases. The study involves 2,000 participants aged 55 and older and aims to directly address these disparities by implementing targeted interventions to enhance cognitive function and overall brain health.
CONDITIONS
Official Title
The INSPIRE Study: Intervention Strategies for Preserving Intellectual Resilience and Engagement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be 55 years of age or older.
- Focused on African American individuals, but not exclusive.
- Participants must have normal cognitive status, mild cognitive impairment (MCI), or subjective cognitive impairment (SCI).
- Participants must be fluent in English.
- Must reside in the Crenshaw, California area or be able to attend study-related activities in this location.
- Participants must be willing to adhere to the study protocol, including attending assessments, participating in interventions, and completing questionnaires.
You will not qualify if you...
- Diagnosis of dementia or severe cognitive impairment that would interfere with the ability to participate in the study.
- Any physical or medical condition that would preclude participation in the lifestyle interventions (e.g., severe mobility issues).
- Diagnosis of cancer within the last three years, excluding stable cases of basal cell or squamous cell carcinoma of the skin, or stable prostate cancer.
- Current pregnancy or planning to become pregnant during the study period.
- Diagnosis of severe psychiatric disorders such as schizophrenia or bipolar disorder that might interfere with participation.
- Current substance abuse or dependency that could impact participation.
- Uncorrected hearing loss that would limit the ability to communicate and participate in the study.
- Inability to participate in English-language oral and written cognitive assessments.
- Currently enrolled in another clinical trial that could interfere with the INSPIRE Study.
- Life expectancy less than 3 years
- Unwillingness to share medical and laboratory information.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Crenshaw Christian Center
Los Angeles, California, United States, 90044
Actively Recruiting
Research Team
D
Dean Sherzai, MD, PhD
CONTACT
C
Caroline Segalla, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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