Actively Recruiting

All Genders
NCT06645899

Institution of an Italian Multicenter Database of Patients Affected by Hypoparathyroidism or Pseudohypoparathyroidism

Led by F.I.R.M.O. - Fondazione Italiana Ricerca sulle Malattie dell'Osso - Ente del Terzo Settore · Updated on 2025-01-23

600

Participants Needed

41

Research Sites

521 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this observational study is to create, manage and analyze a multicenter national database of patients affected by hypoparathyroidism or pseudohypoparathyroidism, aimed at collecting and studying anamnestic, diagnostic, genetic, clinical, and therapeutic data in a relatively wide number of patients with these two rare pathologies, in Italy. The study will include 41 specialist clinical centers of endocrinology, pediatric endocrinology, pediatrics, and endocrine surgery, located throughout the Italian territory, and to which patients refer from all the 20 regions of Italy. Data will be collected over time, both in retrospective and prospective manners, during the 10-year duration of the study, starting from the recruiting visit (basal visit) and then during each follow-up visits patients will undergo for the control of disease at the recruiting clinical centers. Collected data will include both the most classic traits of the pathology and the less common ones, with the final goal of refining and deepening medical knowledge in the field of these two clinical conditions affecting parathyroid function and calcium homeostasis, and, thus, to be able to define optimal clinical and therapeutic management of patients, improving their quality of life. The main aspects this observational study aims to assess and clarify are: 1. Evaluation of prevalence and incidence of hypoparathyroidism, globally and in its different etiological forms, and of pseudohypoparathyroidism in Italy. 2. Clinical characterization of different etiological forms of hypoparathyroidism, through both cross-sectional and longitudinal analyses of collected data. 3. Clinical characterization of pseudohypoparathyroidism, through both cross-sectional and longitudinal analyses of collected data. 4. Over time collection of data on bone status and bone fragility in patients with hypoparathyroidism and pseudohypoparathyroidism, to evaluate the prevalence and incidence of fragility fractures in these patients, globally and also based on gender, age, and disease etiology. 5. Over time evaluation of response to pharmacological therapies in patients with hypoparathyroidism and pseudohypoparathyroidism The study will include two independent cohorts of female and male patients of any age, one including patients with chronic hypoparathyroidism of each etiological forms (cohort 1), and one including patients with pseudohypoparathyroidism (cohort 2). The study does not include either any control group/comparison group or healthy volunteers. The study itself does not involve any medical intervention or drug administration. Pharmacological treatments for which data on response to therapy will be collected in the database, are those administered to patients for the control/treatment of hypoparathyroidism or pseudohypoparathyroidism, regardless of their inclusion in this observational study.

CONDITIONS

Official Title

Institution of an Italian Multicenter Database of Patients Affected by Hypoparathyroidism or Pseudohypoparathyroidism

Who Can Participate

All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosed with chronic hypoparathyroidism of any cause
  • Diagnosed with pseudohypoparathyroidism
Not Eligible

You will not qualify if you...

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety

AI-Screening

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Trial Site Locations

Total: 41 locations

1

SC Pediatria e Pronto Soccorso Pediatrico - AOU SS. Antonio e Biagio e C. Arrigo

Alessandria, Italy

Not Yet Recruiting

2

U.O.C. Endocrinologia, Azienda Ospedaliero Universitaria Policlinico Consorziale, Università degli Studi di Bari "Aldo Moro"

Bari, Italy

Not Yet Recruiting

3

Unità di Pediatria, IRCCS Azienda Ospedaliero-Universitaria di Bologna

Bologna, Italy

Not Yet Recruiting

4

UOC Endocrinologia e Prevenzione e Cura del Diabete, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Alma Mater Studiorum Università di Bologna

Bologna, Italy

Not Yet Recruiting

5

Centro di Auxoendocrinologia e Genetica Medica della Clinica Pediatrica degli Spedali Civili di Brescia

Brescia, Italy

Not Yet Recruiting

6

Endocrinologia e Diabetologia, Azienda Ospedaliero-Universitaria di Cagliari, Presidio Ospedaliero Policlinico di Monserrato

Cagliari, Italy

Not Yet Recruiting

7

UO Endocrinologia e Malattie del Ricambio, Azienda Ospedaliero Universitaria di Ferrara, Sezione di Endocrinologia, Geriatria e Medicina Interna, Dipartimento di Scienze Mediche, Università degli Studi di Ferrara

Ferrara, Italy

Actively Recruiting

8

Diabetologia e Endocrinologia, Auxoendocrinologia, Children's Hospital Meyer IRCCS

Florence, Italy

Not Yet Recruiting

9

SOD Malattie del Metabolismo Minerale ed Osseo, Azienda Ospedaliero-Universitaria Careggi

Florence, Italy

Actively Recruiting

10

Ospedale Casa Sollievo della Sofferenza

Foggia, Italy

Not Yet Recruiting

11

Centro di Alta Specialità in Osteoporosi Pediatrica e Malattie del Metabolismo Calcio-Fosforo, U.O.C. Clinica Pediatrica, Dipartimento di Scienze Pediatriche Generali e Specialistiche IRCCS Istituto Giannina Gaslini

Genova, Italy

Not Yet Recruiting

12

Clinica Endocrinologica, Dipartimento di Medicina Interna e Specialità Mediche (DiMI), IRCCS Ospedale Policlinico San Martino, Università di Genova

Genova, Italy

Not Yet Recruiting

13

U.O.S.D. Centro Malattie Rare · Dipartimento di Pediatria IRCCS Ospedale Pediatrico Giannina Gaslini

Genova, Italy

Not Yet Recruiting

14

Dipartimento di Patologia Umana dell'adulto e dell'età evolutiva "Gaetano Barresi", Università degli Studi di Messina

Messina, Italy

Not Yet Recruiting

15

UOC di Endocrinologia, AOU Policlinico G. Martino, Dipartimento di Patologia Umana DETEV, Università di Messina

Messina, Italy

Not Yet Recruiting

16

Dipartimento di Malattie Endocrino-Metaboliche, IRCCS Istituto Auxologico Italiano

Milan, Italy

Not Yet Recruiting

17

Endocrinologia Infantile, UOU di Pediatria, IRCCS Ospedale San Raffaele

Milan, Italy

Not Yet Recruiting

18

IRCCS Ospedale San Raffaele

Milan, Italy

Not Yet Recruiting

19

SC Endocrinologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, Italy

Not Yet Recruiting

20

Dipartimento di Medicina Clinica e Chirurgia; Unità di Endocrinologia, Diabetologia e Andrologia; Università degli Studi di Napoli Federico II

Naples, Italy

Not Yet Recruiting

21

UOC di Endocrinologia e Malattie del Metabolismo, AOU Università degli Studi della Campania Luigi Vanvitelli

Naples, Italy

Not Yet Recruiting

22

UOS di Endocrinologia Pediatrica, Dipartimento Materno Infantile, AOU Federico II

Naples, Italy

Not Yet Recruiting

23

UOSD Malattie Neuro-Endocrine, Centro Obesità, Dipartimento di Neuroscienze e Riabilitazione, AORN Santobono-Pausilipon

Naples, Italy

Not Yet Recruiting

24

SCDU Endocrinologia Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara

Novara, Italy

Not Yet Recruiting

25

Endocrinologia, Clinica Polispecialistica San Carlo

Paderno Dugnano, Italy

Not Yet Recruiting

26

Unità di Chirurgia Endocrina, Dipartimento di Chirurgia, Oncologia e Gastroenterologia, Università di Padova

Padova, Italy

Not Yet Recruiting

27

UOC Endocrinologia, DIMED, Azienda Ospedaliero-Universitaria di Padova

Padova, Italy

Not Yet Recruiting

28

Unità Operativa Endocrinologia 2, Azienda Ospedaliera Universitaria Pisana

Pisa, Italy

Not Yet Recruiting

29

Dipartimento di Medicina Sperimentale, "Sapienza" Università di Roma, Roma - UOC Endocrinologia, Policlinico Umberto I di Roma

Roma, Italy

Not Yet Recruiting

30

Unità di Endocrinologia e Andrologia, Dipartimento di Medicina Clinica e Molecolare, AOU Sant'Andrea, Centro di eccellenza ENETS, Università Sapienza di Roma

Roma, Italy

Not Yet Recruiting

31

UOC di Endocrinologia e Diabetologia, UOS di Endocrinologia Pediatrica, IRCCS Ospedale Pediatrico Bambino Gesù

Roma, Italy

Not Yet Recruiting

32

UOC Patologie osteo-metaboliche e della tiroide, Fondazione Policlinico universitario Campus Bio-Medico

Roma, Italy

Not Yet Recruiting

33

UOC di Endocrinologia, Diabetologia e Andrologia Medica, IRCCS Humanitas Research Hospital

Rozzano, Italy

Not Yet Recruiting

34

Donatello Bone Clinic, Casa di Cura Villa Donatello

Sesto Fiorentino, Italy

Actively Recruiting

35

Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, Policlinico Santa Maria delle Scotte, Università di Siena

Siena, Italy

Not Yet Recruiting

36

Endocrinologia Pediatrica Ospedale Infantile regina Margherita-Dipartimento di Scienze di Sanità Pubblica e Pediatriche, Università degli studi di Torino

Torino, Italy

Not Yet Recruiting

37

SCDU Endocrinologia Diabetologia e Malattie del Metabolismo, AOU Città della Salute e della Scienza di Torino, Università di Torino

Torino, Italy

Not Yet Recruiting

38

SCDU Endocrinologia Oncologica, AOU Città della Salute e della Scienza di Torino, Università di Torino

Torino, Italy

Not Yet Recruiting

39

IRCCS Materno-Infantile Burlo Garofolo

Trieste, Italy

Actively Recruiting

40

SOC Endocrinologia, Azienda Sanitaria-Universitaria Friuli Centrale

Udine, Italy

Not Yet Recruiting

41

UOS di Endocrinologia, Policlinico GB Rossi, Azienda Ospedaliera Universitaria Integrata di Verona

Verona, Italy

Not Yet Recruiting

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Research Team

M

Maria Luisa Brandi, MD, PhD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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