Building and Managing a National Italian Database for Patients with Parathyroid Carcinoma or Atypical Parathyroid Adenoma to Improve Understanding and Treatment

What this Trial Is About

Researchers are creating and managing a national multicenter database in Italy to study patients with parathyroid carcinoma or atypical parathyroid adenoma, two very rare types of parathyroid gland cancers. The study aims to collect and analyze detailed clinical, genetic, diagnostic, histological, and therapeutic data from a wide number of patients across 33 specialist centers throughout Italy. This observational research seeks to improve understanding of these rare tumors and guide better clinical and therapeutic management. The study involves two patient groups those with parathyroid carcinoma and those with atypical parathyroid adenoma, including both sporadic and genetic forms of the diseases. Data will be collected both retrospectively from medical records and prospectively during routine follow-up visits over a 10-year period. Treatments such as surgery and medications are those conventionally used for these conditions, with no additional interventions or visits required by the study. Participants will have their medical history, diagnostic tests, biochemical and genetic data, treatments, and follow-up outcomes recorded anonymously in the database. Researchers will assess disease prevalence, tumor characteristics, and responses to therapy over short and long terms. The study spans approximately 10 years, during which ongoing clinical data is gathered to refine medical knowledge and improve patient care for these rare parathyroid cancers.

Institution of an Italian Multicenter Database of Patients with Parathyroid Carcinoma or Atypical Parathyroid Adenoma