Actively Recruiting

All Genders
NCT06645951

Institution of an Italian Multicenter Database of Patients with Parathyroid Carcinoma or Atypical Parathyroid Adenoma

Led by F.I.R.M.O. - Fondazione Italiana Ricerca sulle Malattie dell'Osso - Ente del Terzo Settore · Updated on 2025-01-22

300

Participants Needed

33

Research Sites

521 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this observational study is to create, manage and analyze a multicenter national database of patients with parathyroid carcinoma or atypical parathyroid adenoma, aimed at collecting and studying anamnestic, diagnostic, genetic, clinical, histological, and therapeutic data in a relatively wide number of patients in Italy. The study will include 33 specialist clinical centers of endocrinology and endocrine surgery, located throughout the Italian territory, and to which patients refer from all the 20 regions of Italy. Data will be collected over time, both in retrospective and prospective manners, during the 10-year duration of the study, starting from the recruiting visit (basal visit) and then during each follow-up visits patients will undergo for the control of disease progression at the recruiting clinical centers. Collected data will include both the most classic traits of the pathology and the less common ones, with the final goal of refining and deepening medical knowledge in the field of these two extremely rare parathyroid cancers and be able to define optimal clinical and therapeutic management of patients, improving their quality and life expectancy. The main aspects this observational study aims to assess and clarify are: 1. Evaluation of prevalence and incidence of parathyroid carcinoma and atypical parathyroid adenoma in Italy, both as sporadic disease or in the context of genetic disorders. 2. Clinical, histological, and biochemical characterization of parathyroid carcinoma vs atypical parathyroid adenoma, to assess features and aspects that distinguish these two kinds of tumors and may help in the differential diagnosis. 3. Evaluation of short-term and long-term response to therapies in patients with parathyroid carcinoma and in patients with atypical parathyroid adenoma to assess possible differences between these two types of cancer and, thus, to design tailored clinical and therapeutic managements for patients. 4. Evaluation of short-term and long-term response to therapies in sporadic forms vs genetic forms of parathyroid carcinoma and atypical parathyroid adenoma, to assess possible differences between these two different forms of diseases and, thus, to design tailored clinical and therapeutic managements for patients. The study will include two independent cohorts of female and male patients of any age, one including patients who developed parathyroid carcinoma (cohort 1) and one including patients who developed atypical parathyroid adenoma (cohort 2), both as sporadic cancer or in the context of genetic diseases. The study does not include either any control group/comparison group or healthy volunteers. The study itself does not involve any medical intervention or drug administration. Treatments (surgery and/or drugs), for which data on response to therapy will be collected in the database, are those that are conventionally used in patients with parathyroid carcinoma or atypical parathyroid adenoma for treatment of their pathology, regardless of their inclusion in this observational study.

CONDITIONS

Official Title

Institution of an Italian Multicenter Database of Patients with Parathyroid Carcinoma or Atypical Parathyroid Adenoma

Who Can Participate

All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of parathyroid carcinoma (Cohort 1)
  • Diagnosis of atypical parathyroid adenoma (Cohort 2)
Not Eligible

You will not qualify if you...

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety

AI-Screening

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Trial Site Locations

Total: 33 locations

1

U.O.C. Endocrinologia, Azienda Ospedaliero Universitaria Policlinico Consorziale, Università degli Studi di Bari "Aldo Moro"

Bari, Italy

Not Yet Recruiting

2

UOC Endocrinologia e Prevenzione e Cura del Diabete, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Alma Mater Studiorum Università di Bologna

Bologna, Italy

Not Yet Recruiting

3

Endocrinologia e Diabetologia, Azienda Ospedaliero-Universitaria di Cagliari, Presidio Ospedaliero Policlinico di Monserrato

Cagliari, Italy

Not Yet Recruiting

4

UO Endocrinologia e Malattie del Ricambio, Azienda Ospedaliero Universitaria di Ferrara, Sezione di Endocrinologia, Geriatria e Medicina Interna, Dipartimento di Scienze Mediche, Università degli Studi di Ferrara

Ferrara, Italy

Actively Recruiting

5

SOD Malattie del Metabolismo Minerale ed Osseo, Azienda Ospedaliero-Universitaria Careggi

Florence, Italy

Actively Recruiting

6

Unità di Chirurgia Endocrina, Azienda Ospedaliero-Universitaria Careggi

Florence, Italy

Not Yet Recruiting

7

Ospedale Casa Sollievo della Sofferenza

Foggia, Italy

Not Yet Recruiting

8

Clinica Endocrinologica, Dipartimento di Medicina Interna e Specialità Mediche (DiMI), IRCCS Ospedale Policlinico San Martino, Università di Genova

Genova, Italy

Not Yet Recruiting

9

Clinica Pediatrica ed Endocrinologia, IRCCS Ospedale Pediatrico Giannina Gaslini

Genova, Italy

Not Yet Recruiting

10

U.O.S.D. Centro Malattie Rare · Dipartimento di Pediatria IRCCS Ospedale Pediatrico Giannina Gaslini

Genova, Italy

Not Yet Recruiting

11

UOC di Endocrinologia, AOU Policlinico G. Martino, Dipartimento di Patologia Umana DETEV, Università di Messin

Messina, Italy

Not Yet Recruiting

12

Dipartimento di Malattie Endocrino-Metaboliche, IRCCS Istituto Auxologico Italiano

Milan, Italy

Not Yet Recruiting

13

Endocrinologia Infantile, UOU di Pediatria, IRCCS Ospedale San Raffaele

Milan, Italy

Not Yet Recruiting

14

IRCCS Ospedale San Raffaele

Milan, Italy

Not Yet Recruiting

15

SC Endocrinologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, Italy

Not Yet Recruiting

16

Dipartimento di Medicina Clinica e Chirurgia; Unità di Endocrinologia, Diabetologia e Andrologia; Università degli Studi di Napoli Federico II

Naples, Italy

Actively Recruiting

17

UOC di Endocrinologia e Malattie del Metabolismo, AOU Università degli Studi della Campania Luigi Vanvitelli

Naples, Italy

Not Yet Recruiting

18

SCDU Endocrinologia Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara

Novara, Italy

Not Yet Recruiting

19

Endocrinologia, Clinica Polispecialistica San Carlo

Paderno Dugnano, Italy

Not Yet Recruiting

20

Unità di Chirurgia Endocrina, Dipartimento di Chirurgia, Oncologia e Gastroenterologia, Università di Padova

Padova, Italy

Not Yet Recruiting

21

UOC Endocrinologia, DIMED, Azienda Ospedaliero-Universitaria di Padova

Padova, Italy

Not Yet Recruiting

22

Unità Operativa Endocrinologia 2, Azienda Ospedaliera Universitaria Pisana

Pisa, Italy

Not Yet Recruiting

23

Dipartimento di Medicina Sperimentale, "Sapienza" Università di Roma, Roma - UOC Endocrinologia, Policlinico Umberto I di Roma

Roma, Italy

Not Yet Recruiting

24

Unità di Endocrinologia e Andrologia, Dipartimento di Medicina Clinica e Molecolare, AOU Sant'Andrea, Centro di eccellenza ENETS, Università Sapienza di Roma

Roma, Italy

Not Yet Recruiting

25

UOC Patologie osteo-metaboliche e della tiroide, Fondazione Policlinico universitario Campus Bio-Medico

Roma, Italy

Not Yet Recruiting

26

UOC di Endocrinologia, Diabetologia e Andrologia Medica, IRCCS Humanitas Research Hospital

Rozzano, Italy

Not Yet Recruiting

27

Donatello Bone Clinic, Casa di Cura Villa Donatello

Sesto Fiorentino, Italy

Actively Recruiting

28

Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, Policlinico Santa Maria delle Scotte, Università di Siena

Siena, Italy

Not Yet Recruiting

29

SCDU Endocrinologia Diabetologia e Malattie del Metabolismo, AOU Città della Salute e della Scienza di Torino, Università di Torino

Torino, Italy

Not Yet Recruiting

30

SCDU Endocrinologia Oncologica, AOU Città della Salute e della Scienza di Torino, Università di Torino

Torino, Italy

Not Yet Recruiting

31

IRCCS Materno-Infantile Burlo Garofolo

Trieste, Italy

Not Yet Recruiting

32

SOC Endocrinologia, Azienda Sanitaria-Universitaria Friuli Centrale

Udine, Italy

Not Yet Recruiting

33

UOS di Endocrinologia, Policlinico GB Rossi, Azienda Ospedaliera Universitaria Integrata di Verona

Verona, Italy

Not Yet Recruiting

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Research Team

M

Maria Luisa Brandi, MD, PhD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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