Study of Insulin Resistance and Coronary Microvascular Dysfunction in Adults with Myocardial Ischemia and Non-obstructive Coronary Artery Disease

What this Trial Is About

Researchers are investigating the relationship between coronary microvascular dysfunction and insulin resistance in adults with myocardial ischemia but without obstructive coronary artery disease INOCA. This prospective, experimental study aims to explore how these conditions may be connected in patients without diabetes. Participants will be followed for two years to monitor their health outcomes and clinical status. Participants will undergo a series of diagnostic tests including coronary angiography to assess their coronary arteries and exclude obstructive disease. Those with non-obstructive findings will have their coronary microvascular function evaluated using thermodilution methods. Insulin resistance will be measured through a hyperinsulinemic-euglycemic clamp test. Additional assessments include echocardiography, fasting glucose and insulin tests, HOMA index, glycated hemoglobin, and oral glucose tolerance tests. Follow-up visits will occur at 6 and 12 months with some tests repeated to monitor changes. Throughout the study, participants will have clinical evaluations, blood tests, and heart function imaging to track their condition. Researchers will measure the correlation between coronary microvascular dysfunction and insulin resistance at the start, assess vasomotor function, and record any adverse clinical events over 12 months. Safety and health status will be monitored regularly, with follow-up continuing for two years to better understand the progression and interaction of these conditions.

Insulin Resistance and Coronary Microvascular Dysfunction in Patients with Myocardial Ischemia and Non-obstructive Coronary Artery Disease