Actively Recruiting
Insulin Resistance and Coronary Microvascular Dysfunction in Patients with Myocardial Ischemia and Non-obstructive Coronary Artery Disease
Led by Azienda Ospedaliera Universitaria Integrata Verona · Updated on 2024-09-19
40
Participants Needed
1
Research Sites
105 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this prospective study is to assess the correlation between coronary microvascular disfunction and insulin resistance in patients with INOCA. Patients with ANOCA and without diabetes will undergo invasive coronary microvascular assessment through coronary angiography and insulin resistance assessment through hyperinsulinemic-euglycemic clamp test. Patients enrolled in the study will be followed for a period of 2 years to monitor their clinical status.
CONDITIONS
Official Title
Insulin Resistance and Coronary Microvascular Dysfunction in Patients with Myocardial Ischemia and Non-obstructive Coronary Artery Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged over 18 years.
- Cardiac chest pain with evidence of myocardial ischemia at noninvasive myocardial stress imaging and clinical indication to diagnostic coronary angiography
- Willing and able to give informed consent for participation in the study
You will not qualify if you...
- Obstructive CAD (defined as more than 70% luminal stenosis and/or FFR 40.80 in 1 or more epicardial vessels).
- History of previous myocardial infarction, percutaneous revascularization or coronary-aortic bypass graft (CABG) surgery.
- Diagnosis of type II diabetes.
- BMI 3 35 kg/m2.
- Stage IV and V of chronic kidney disease (eGFR 4 30 ml/min, estimated through CKD - EPI Creatinine Equation).
- Allergy or other contraindication to iodinated contrast and/or gadolinium and/or adenosine.
- Chronic resting O2 saturation 4 85%.
- Pregnancy or suspected pregnancy.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Azienda Ospedaliera Universitaria di Verona
Verona, VR, Italy, 37126
Actively Recruiting
Research Team
N
Natascia Antonioli
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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