Actively Recruiting
Insulin Resistance in Multiple System Atrophy
Led by University Hospital, Bordeaux · Updated on 2025-07-20
124
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Bordeaux
Lead Sponsor
U
University of Bordeaux
Collaborating Sponsor
AI-Summary
What this Trial Is About
Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder. The pathologic hallmark is the accumulation of aggregated alpha-synuclein in oligodendrocytes forming glial cytoplasmic inclusions. Some symptomatic treatments are available while disease-modification remains an unmet treatment need. Post-mortem findings suggest insulin resistance, i.e. reduced insulin signaling, in the brains of MSA patients. The aim of this study is to complete the target validation of insulin resistance for future treatment trials.
CONDITIONS
Official Title
Insulin Resistance in Multiple System Atrophy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with possible or probable multiple system atrophy (MSA) based on clinical criteria
- Age over 30 years
- Ability to provide written informed consent
- Coverage by the national health system
- Control participants without neurological disorders
- Controls aged over 30 years
- Controls able to provide written informed consent
- Controls covered by the national health system
You will not qualify if you...
- Diagnosis of diabetes
- Treatment with corticosteroids, estrogen, atypical antipsychotics, or anti-retroviral drugs
- Patient under legal guardianship
- Inability to give consent
- Presence of any other neurological disorder
- Pregnancy or breastfeeding
- Montreal Cognitive Assessment (MOCA) score less than or equal to 21
- Contraindications to undergoing MRI scans
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU de Bordeaux
Bordeaux, France, 33 076
Actively Recruiting
Research Team
W
Wassilios MEISSNER
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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