Actively Recruiting
Insulin Sensitivity After Breast Cancer
Led by University of Copenhagen · Updated on 2021-08-18
24
Participants Needed
1
Research Sites
265 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Epidemiological studies have revealed that 60-80% of women with breast cancer (BC) develop metabolic disorders that are similar to those observed in conditions like type 2 diabetes. These metabolic disorders, including insulin resistance, obesity, hyperinsulinemia, and glucose intolerance, are associated with increased BC recurrence and mortality. Skeletal muscle is the major site of glucose uptake in humans. The aims of the present project are to 1) determine the involvement of insulin resistance in skeletal muscle in the metabolic disorders prevalent in BC survivors, 2) identify BC-and/or treatment-induced molecular changes in skeletal muscle from BC survivors .
CONDITIONS
Official Title
Insulin Sensitivity After Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Premenopausal women operated for breast cancer and after completing adjuvant chemotherapy and no earlier than 3 weeks after its termination
- Body Mass Index between 25 and 30
- Healthy controls matched by gender, weight, age, and physical activity level to the patient group
You will not qualify if you...
- Known postmenopause at the time of breast cancer diagnosis
- Alcohol intake of more than 7 items per week
- Current smoker
- Known type 2 diabetes mellitus or metabolic syndrome and medical treatment for these conditions
- Cardiovascular disease and medical treatment for it
- Impaired mobility
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Copenhagen
Copenhagen, DK, Denmark, 2100
Actively Recruiting
Research Team
L
Lykke Sylow, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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