Actively Recruiting
Integrated Echocardiography and Chest Ultrasound Assessment of Lung Recruitment in Preterm Infants Using High Frequency Ventilation
Led by Alexandria University · Updated on 2025-05-28
72
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the use of high frequency oscillatory ventilation (HFOV) to help open the lungs in preterm newborns born between 32 and 37 weeks gestational age who have moderate to severe breathing difficulties. The study also aims to compare chest ultrasound with routine chest X-rays to monitor lung opening and to assess heart function using functional echocardiography. This research is focused on improving care for these vulnerable infants by evaluating these monitoring methods and ventilation support. The study involves preterm infants who require invasive breathing support through HFOV within the first 24 hours of life. Researchers will use chest ultrasound and echocardiography to monitor lung recruitment and heart blood flow during this treatment. The main study period covers the first three days after birth when these assessments will be performed to evaluate lung and heart function. Participants will undergo chest ultrasound exams and heart flow measurements during the initial three days of life. The study will measure lung recruitment using ultrasound, blood flow through the superior vena cava, and estimated pulmonary artery pressure. These assessments will help researchers understand the effects of HFOV on lung opening and heart function in preterm babies. The total participation time is around three days with ongoing monitoring during this period.
CONDITIONS
Brief Title
Integrated Echocardiography and Chest Ultrasound Assessment of Lung Recruitment in Preterm Infants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Infants 32 to 37 weeks gestational age
- Respiratory distress within the first 24 hours of life
- Intubated and receiving invasive respiratory support using high frequency oscillatory ventilation (HFOV)
- Signs of respiratory distress include fast breathing (respiratory rate > 60/min), grunting, nasal flaring, chest retractions, or need for oxygen or respiratory support
You will not qualify if you...
- Known major congenital anomalies including congenital heart diseases
- Fetal hydrops
- Babies with congenital heart diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - First 3 days after birth
Participants receive lung recruitment using high frequency ventilation and are assessed with chest ultrasound and echocardiography.
Daily visits for up to 3 days
Trial Site Locations
Total: 2 locations
1
Marwa Mohamed Farag
Alexandria, Egypt, 0325
Actively Recruiting
2
Neonatal Intensive Care Unit (NICU) of Alexandria University Maternity Hospital.
Alexandria, Egypt, 21131
Not Yet Recruiting
Research Team
M
Marwa M Farag, PhD
M
Mohamed Hany Saad, MBBCh
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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