Actively Recruiting

Phase Not Applicable
Age: 1Hour - 3Days
All Genders
ID05726578

Integrated Echocardiography and Chest Ultrasound Assessment of Lung Recruitment in Preterm Infants Using High Frequency Ventilation

Led by Alexandria University · Updated on 2025-05-28

72

Participants Needed

2

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying the use of high frequency oscillatory ventilation (HFOV) to help open the lungs in preterm newborns born between 32 and 37 weeks gestational age who have moderate to severe breathing difficulties. The study also aims to compare chest ultrasound with routine chest X-rays to monitor lung opening and to assess heart function using functional echocardiography. This research is focused on improving care for these vulnerable infants by evaluating these monitoring methods and ventilation support. The study involves preterm infants who require invasive breathing support through HFOV within the first 24 hours of life. Researchers will use chest ultrasound and echocardiography to monitor lung recruitment and heart blood flow during this treatment. The main study period covers the first three days after birth when these assessments will be performed to evaluate lung and heart function. Participants will undergo chest ultrasound exams and heart flow measurements during the initial three days of life. The study will measure lung recruitment using ultrasound, blood flow through the superior vena cava, and estimated pulmonary artery pressure. These assessments will help researchers understand the effects of HFOV on lung opening and heart function in preterm babies. The total participation time is around three days with ongoing monitoring during this period.

CONDITIONS

Brief Title

Integrated Echocardiography and Chest Ultrasound Assessment of Lung Recruitment in Preterm Infants

Who Can Participate

Age: 1Hour - 3Days
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Infants 32 to 37 weeks gestational age
  • Respiratory distress within the first 24 hours of life
  • Intubated and receiving invasive respiratory support using high frequency oscillatory ventilation (HFOV)
  • Signs of respiratory distress include fast breathing (respiratory rate > 60/min), grunting, nasal flaring, chest retractions, or need for oxygen or respiratory support
Not Eligible

You will not qualify if you...

  • Known major congenital anomalies including congenital heart diseases
  • Fetal hydrops
  • Babies with congenital heart diseases

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 screening and enrollment visit (in-person)

Treatment

Duration - First 3 days after birth

Participants receive lung recruitment using high frequency ventilation and are assessed with chest ultrasound and echocardiography.

Daily visits for up to 3 days

Trial Site Locations

Total: 2 locations

1

Marwa Mohamed Farag

Alexandria, Egypt, 0325

Actively Recruiting

2

Neonatal Intensive Care Unit (NICU) of Alexandria University Maternity Hospital.

Alexandria, Egypt, 21131

Not Yet Recruiting

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Research Team

M

Marwa M Farag, PhD

M

Mohamed Hany Saad, MBBCh

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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