Actively Recruiting
An Integrated Intervention Using a Pill Ingestible Sensor System
Led by University of California, Los Angeles · Updated on 2026-02-13
110
Participants Needed
1
Research Sites
132 weeks
Total Duration
On this page
Sponsors
U
University of California, Los Angeles
Lead Sponsor
L
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study integrates technology-based adherence measures with alerts for social and behavioral determinants of health (SBDOH) to improve HIV treatment outcomes. It involves 110 adult patients from a Los Angeles County HIV clinic, focusing on those at risk for poor adherence. Participants will be randomized into intervention or usual care groups, with endpoints including intervention acceptability, SBDOH interventions, adherence to ART, viral load, and high-risk sexual activity. The study aims to assess the effectiveness of the integrated intervention in improving adherence, virologic outcomes, and reducing high-risk behavior among PLWH.
CONDITIONS
Official Title
An Integrated Intervention Using a Pill Ingestible Sensor System
Who Can Participate
Eligibility Criteria
You may qualify if you...
- HIV-infected individuals in HIV care
- Age greater than 17 years
- Ability to take co-encapsulated antiretroviral medications at screening
- Able to provide informed consent
- Receiving ART with sub-optimal adherence (self-reported less than 90% adherence in last 28 days) or at high risk for sub-optimal adherence or with known social and behavioral challenges
- Currently receiving antiretroviral treatment that includes one of the specified regimens: TDF/FTC (Truvada), TAF/FTC (Descovy), EFV/FTC/TDF (Atripla), ABC/3TC (Epzicom), DTG/ABC/3TC (Triumeq), RPV/TAF/FTC (Odefsey), EVG/c/FTC/TAF (Genvoya), or BIC/FTC/TAF (Biktarvy)
- For participants of reproductive potential, negative serum or urine pregnancy test at screening and study entry
- Participants not of reproductive potential defined by amenorrhea criteria or surgical sterilization
You will not qualify if you...
- Inability to follow study procedures due to mental confusion, disorganization, intoxication, withdrawal, or risky/threatening behavior
- Pregnancy at screening or study entry
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Lundquist
Los Angeles, California, United States, 90502
Actively Recruiting
Research Team
J
Jie Shen, PhD
CONTACT
Y
Yilan Huang, M.S.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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