Actively Recruiting
Integrated Molecular and Clinical Profiling of Transformed Splenic Marginal Zone Lymphoma
Led by International Extranodal Lymphoma Study Group (IELSG) · Updated on 2026-01-16
100
Participants Needed
7
Research Sites
176 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Histological transformation in Splenic Marginal Zone Lymphoma (t-SMZL) represents an unmet clinical and biological need, invariably associated with poor prognosis and reduced overall survival. At the present time, there are no recommended treatments intended specifically to t-SMZL and little is known about t-SMZL genetic complexity. The aim of this study is to provide information that will help clinicians to better understand the complexity of the disease. The information gained from this study will also lead to more specific and effective treatment for patients with t-SMZL.
CONDITIONS
Official Title
Integrated Molecular and Clinical Profiling of Transformed Splenic Marginal Zone Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older, regardless of gender
- Diagnosis of histological transformation of Splenic Marginal Zone Lymphoma at baseline or during disease course
- Availability of diagnostic tumor material from spleen, lymph node, extra nodal site, peripheral blood, or bone marrow collected at transformation
- Availability of tumor material from spleen, peripheral blood, or bone marrow collected at SMZL diagnosis, if available
- Availability of baseline and follow-up clinical annotations
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Columbia University
New York, New York, United States, 10032
Not Yet Recruiting
2
Universitz Hospitals Leuven
Leuven, Belgium, 3000
Not Yet Recruiting
3
Hôpital Saint Louis
Paris, France, 75475
Actively Recruiting
4
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy, 27100
Actively Recruiting
5
Hospital Clínic de Barcelona
Barcelona, Spain, 08036
Actively Recruiting
6
Oncology Institute of Southern Switzerland
Bellinzona, Switzerland, 6500
Not Yet Recruiting
7
University Hospitals Dorset
Bournemouth, United Kingdom, BH7 7DW
Not Yet Recruiting
Research Team
I
IELSG Study Coordination Office
CONTACT
D
Davide Rossi, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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