Actively Recruiting
Integrated Treatment for Opioid Use Disorder and PTSD
Led by Medical University of South Carolina · Updated on 2025-11-28
76
Participants Needed
1
Research Sites
126 weeks
Total Duration
On this page
Sponsors
M
Medical University of South Carolina
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will test a therapy intervention, HOPE, for individuals with opioid use disorder and posttraumatic stress disorder. Interested individuals will need to be taking medications for opioid use disorder (e.g., suboxone, naltrexone, methadone). Interested participants will complete a 10-12 week therapy, and be asked to complete surveys.
CONDITIONS
Official Title
Integrated Treatment for Opioid Use Disorder and PTSD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Any gender; any race or ethnicity; aged 18-70 years old.
- English-speaking.
- Meet DSM-5 diagnostic criteria for opioid use disorder.
- Meet DSM-5 diagnostic criteria for posttraumatic stress disorder and have some memory of their traumatic event.
- Must be maintained on a stable dose of medication for opioid use disorder for at least 1 month.
- Participants on psychotropic medications must be on a stable dose for at least 1 month before starting the study.
You will not qualify if you...
- Participants with unmanaged psychiatric conditions such as psychosis, mania, or bipolar disorder.
- Participants at immediate suicide risk with current suicidal thoughts and a plan, or exhibiting other high-risk behaviors.
- Participants with a primary non-opioid substance use disorder.
- Participants currently enrolled in other evidence-based psychotherapy for substance use disorders or PTSD outside of standard medication or group therapy.
- Participants with medical conditions requiring immediate intensive treatment, such as unstable end-stage liver disease.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29403
Actively Recruiting
Research Team
T
Tanya C Saraiya, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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