Actively Recruiting
Integrating AI in Postural Rehabilitation for Parkinson's Disease
Led by IRCCS National Neurological Institute "C. Mondino" Foundation · Updated on 2025-06-08
20
Participants Needed
1
Research Sites
217 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Postural abnormalities are highly disabling complications of Parkinson's disease (PD). These include camptocormia, anterocollis, and Pisa Syndrome (PS). PS is characterized by a lateral trunk flexion (LTF) typically exceeding 10 degrees, often accompanied by axial rotation, asymmetric shoulder positioning, and poor awareness of the postural alteration. This condition worsens during upright activities and improves in a supine position. Patients with PD and PS are characterized by more pronounced motor asymmetry, a disorganized trunk muscle activity, back pain, balance issues, and reduced quality of life compared to PD patients without postural disorders. Camptocormia, another disabling postural anomaly, involves an anterior trunk flexion that also improves when lying down. Both PS and camptocormia are challenging to treat, with limited and short-lasting benefits from current multidisciplinary approaches, including medication, physiotherapy, botulinum toxin injections, and transcranial direct current stimulation (tDCS). Given the limitations of traditional rehabilitation strategies, there is a growing need for innovative and personalized approaches. In this context, advanced technologies such as artificial intelligence (AI) offer new possibilities for home-based treatment. This study aims to evaluate the feasibility of using a real-time visual feedback system powered by AI as a complementary intervention following inpatient neurorehabilitation for PD patients with trunk postural disorders (PS or camptocormia). A secondary objective is to assess whether an AI-guided, personalized exercise program can help maintain improvements in posture, mobility, and quality of life in the medium term. By integrating quantitative and qualitative outcomes, this study seeks to fill a gap in the literature and explore the potential of AI-driven home rehabilitation to support long-term functional gains and foster greater independence and well-being in people with PD.
CONDITIONS
Official Title
Integrating AI in Postural Rehabilitation for Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age above 18 years
- Diagnosis of Parkinson's disease according to MDS criteria
- Hoehn and Yahr stage less than or equal to III
- Clinical diagnosis of camptocormia with anterior trunk flexion of at least 30 degrees or Pisa Syndrome with lateral trunk flexion of at least 10 degrees at enrollment
- Mini-Mental State Examination (MMSE) score greater than 23
You will not qualify if you...
- Atypical parkinsonian syndromes
- History of spinal surgery
- Previous vertebral trauma
- Current or past spinal tumors or infections
- Idiopathic scoliosis
- Ankylosing spondylitis
- Spinal canal stenosis
- Other neurological conditions
- Severe dyskinesias
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
IRCCS Mondino Foundation
Pavullo nel Frignano, Pavia, Italy, 27100
Actively Recruiting
Research Team
R
Roberto De Icco
CONTACT
C
Cinzia Fattore
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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