Actively Recruiting
Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0
Led by Indiana University · Updated on 2025-10-20
120
Participants Needed
1
Research Sites
261 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The proposed research is to determine the clinical efficacy and neurobiological mechanisms of acupuncture analgesia in patients with sickle cell disease.
CONDITIONS
Official Title
Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Any gender
- Age between 14 and 80 years (adolescents 14-17 and adults 18-80)
- Right-handed
- Outpatient or inpatient status, or changing between these
- Diagnosed with sickle cell disease (including SS, SC, or other types) with chronic pain in the past 6 months or vaso-occlusive crisis in the past 12 months
- Currently prescribed pain-relieving medications or approved sickle cell therapies
- Willing to limit new pain medications or treatments during study visits
- Able to travel to the study site for scheduled visits and acupuncture treatments up to twice weekly for 5 weeks
- Fluent in English and able to give written informed consent
- Primarily of African or African-descendant ethnicity but open to all ethnicities
You will not qualify if you...
- Suspected or confirmed Covid-19 infection
- Acupuncture or related alternative pain treatments within the last 6 months
- Known blood clotting problems or bleeding disorders that increase risk with acupuncture
- Other autoimmune or inflammatory diseases causing pain worse than sickle cell pain
- History of significant head injury or loss of consciousness
- Peripheral neuropathy that affects daily activities
- Severe psychiatric illnesses such as schizophrenia or major depression with suicidal thoughts
- Significant vision, movement, or hearing impairments interfering with study participation
- Recent start or dose change of stimulant medications within 30 days
- Contraindications to MRI such as metal implants or cardiac disorders
- History of vascular surgery or current vascular problems in lower limbs
- Current legal or compensation claims related to sickle cell disease
- Participation in other therapeutic trials with similar goals
- Pregnancy or nursing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Indiana University School of Medicine
Indianapolis, Indiana, United States, 46075
Actively Recruiting
Research Team
Y
Ying Wang, MD, PhD
CONTACT
Y
Ying Wang, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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